Results 31 to 40 of about 1,110,686 (244)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In ¡Basta! men also suffer violence [PDF]

open access: yes, 2017
El presente texto aborda la colección de libros denominados: ¡Basta! Cien hombres contra la violencia de género, Argentina (2016) y ¡Basta! + de 100 hombres contra la violencia de género, Chile (2012) con el fin de evidenciar que los hombres también ...
Hernández Peñaloza, Amor
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Hombres y mujeres anuméricos [PDF]

open access: yes, 1997
Postprint (author's final ...
Barceló Garcia, Miquel
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Los volcanes y los hombres [PDF]

open access: yes, 2007
Desde las entrañas de la tierra, los volcanes han creado la atmósfera, el agua de los océanos, y esculpido los relieves del planeta: son, pues, los zahoríes de la vida. Existen volcanes que los hombres explotan o cultivan, y otros sobre los cuales se han
García, Carmen
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Los hombres negros [PDF]

open access: yes, 1888
Autor tomado de prólogo.Port. a dos tintas.Copia digital : Junta de Castilla y León.
Botér, Clorindo   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Whatever Next? Women's Rights in Sáenz de Heredia's Los derechos de la mujer(1962) [PDF]

open access: yes, 2012
This article examines José Luis Sáenz de Heredia's film Los derechos de la mujer (1962), which raises questions about empowering women within the legal arena and mediates historical and cultural anxieties that circulated in more general terms after the ...
Louis, Anja
core   +1 more source

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