Results 41 to 50 of about 168,335 (298)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Estudio y edición crítica de Los hombres del alba de Efraín Huerta [PDF]
, 2016 "Esta tesis trata en primer instancia acerca de la historia textual, la arqueología textual y una lectura de las variantes de Los hombres del alba, seguido de la edición crítica de Los hombres del alba, conformada por el texto crítico, es decir el texto ...
EMILIANO DELGADILLO MARTINEZ
core
travesía del perineo masculino
Cirugía del Uruguay, 2020 Presentado en sesión de 26 de julio de ...
Abel Chifflet
doaj
Hombres en las fronteras de las cárceles femeninas: un estudio etnográfico sobre los días de visita
Sexualidad, Salud y Sociedad: Revista Latinoamericana, 2022 Los estudios relacionados con los días de visitas en las cárceles se centran casi y exclusivamente en las mujeres que realizan esa actividad en instituciones penitenciarias masculinas.
Helena Salgueiro Lermen +1 more
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Oñati Socio-Legal Series, 2015 This paper reviews the experience and actions carried out by Asociación para la Igualdad On:Giz to promote active involvement of men in tackling gender-based violence.
Mikel Otxotorena Fernandez
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source