Results 61 to 70 of about 230,540 (244)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Hombres con traje de chicanos en Chapultepec, retrato

, 1930
Los Chicanos eran hombres que combatían en grupos irregulares entre 1857-1867 les dieron este apodo por lo mal equipado que iban a la ...

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

El ciclo de la violencia en consumidores de sustancias tóxicas

Medisan, 2013
Se efectuó un estudio descriptivo de 46 pacientes consumidores de sustancias tóxicas, pertenecientes al área de salud del Policlínico Docente "Ernesto Guevara de la Serna" de Santiago de Cuba, de enero a julio del 2013, con vistas a valorar la influencia
Irina Eiranova González-Elías, Ariane Hernández Trujillo, Ángela Otero Mustelier   +2 more
doaj  

‘Obligados a ser hombres y vestir como soldados’. Entre imágenes y discursos fundamentales para la “ley” de Obligatoriedad Militar en Chile

Nuevo mundo - Mundos Nuevos, 2008
This research focuses on the concept of gender, most particularly on masculinity, in Chilean history.  By studying newspapers and specialized works published during the last decade of the nineteenth century, it is possible to show how masculine ...
Luis Sánchez Toro
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Human Papillomavirus infection in men residing in Brazil, Mexico, and the USA Infección por Virus de Papiloma Humano en hombres de Brasil, México y EUA

Salud Pública de México, 2008
OBJECTIVE: To assess Human Papillomavirus (HPV) type distribution among men ages 18 years and older recruited from three different countries utilizing a common protocol for sampling HPV detection, and to evaluate whether HPV detection differs by age and ...
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cansancio emocional y rendimiento académico en estudiantes universitarios durante el retorno a clases presenciales

IE Revista de Investigación Educativa de la REDIECH
Este estudio tuvo como objetivos (1) describir el cansancio emocional de los estudiantes universitarios durante el retorno presencial a la universidad, (2) identificar las diferencias por sexo y entre los que combinan estudio y trabajo y los que solo ...
Enrique Ibarra Aguirre, Elizabeth Ibarra Lizárraga, Yeshica Ludim Sánchez Guzmán   +2 more
doaj   +1 more source