Results 101 to 110 of about 1,734,862 (393)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Guiding Hypertension Management Using Different Blood Pressure Monitoring Strategies (GYMNs study): comparison of three different blood pressure measurement methods: study protocol for a randomized controlled trial

Trials, 2019
Background Home blood pressure (BP) and unattended automated BP (uAOBP) monitoring have been recommended by guidelines for the care of hypertensive subjects. However, BP measurements in the peripheral arteries cannot serve as direct substitutes for their
Hao-Min Cheng, Shih-Hsien Sung, Chen-Huan Chen, Wen-Chung Yu, Shu-Mei Yang, Chao-Yu Guo, Shao-Yuan Chuang, Chern-En Chiang   +7 more
doaj   +1 more source

Are home-based exercises effective to reduce blood pressure in hypertensive adults? A systematic review

Clinical Hypertension, 2022
Sedentarism and chronic non-communicable diseases have been a worldwide health problem that is drastically exacerbated by the COVID-19 pandemic social impacts.
Gabriel Dias Rodrigues, Ligia Soares Lima, Nicole Cristine Simões da Silva, Paula Gomes Lopes Telles, Teresa Mell da Mota Silva Rocha, Victor Quintella de Aragão Porto, Viviane Veloso Cardoso, Pedro Paulo da Silva Soares   +7 more
doaj   +1 more source

Comparative effectiveness of fourth-line anti-hypertensive agents in resistant hypertension: A systematic review and meta-analysis. [PDF]

, 2016
Aim We assessed the effectiveness of fourth-line mineralocorticoid receptor antagonists in comparison with other fourth-line anti-hypertensive agents in resistant hypertension.
Douglas, Ian J, Mansfield, Kathryn E, Mathur, Rohini, Root, Adrian A, Sinnott, Sarah-Jo, Smeeth, Liam, Tomlinson, Laurie A   +6 more
core   +3 more sources

Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging

Advanced Functional Materials, EarlyView.
This study demonstrates a bioinspired stabilization strategy for fluorescent gold‐silica nanoparticles. Inspired by natural biosilica maturation, high‐temperature calcination transforms the silica shells, preventing dissolution in cell culture media and intracellular environments.
Wang Sik Lee, Henry Lee, Patricia Taladriz‐Blanco, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +5 more
wiley   +1 more source

Value and application status quo of home blood pressure monitoring in the elderly patients with hypertension

Huli yanjiu, 2018
This article reviewed the diagnostic criteria and methods of home blood pressure monitoring，the blood pressure characteristics of the elderly hypertensive patients，and the application value of home blood pressure monitoring in the elderly hypertensive ...
廖海芬, 陈玲, 李鹏, 韦玉娟, 李文, 涂燕玉, 伊默, 杨连招   +7 more
doaj  

2019 Chinese Hypertension League guidelines on home blood pressure monitoring

The Journal of Clinical Hypertension, 2019
In China, automated blood pressure monitors have been readily available for home use. Home blood pressure monitoring has been indispensable in the management of hypertension.
Ji-Guang Wang, P. Bu, Lu-yuan Chen, Xin Chen, Yuanzhe Chen, Wenjun Cheng, S. Chu, Zhao-qiang Cui, Qiu-yan Dai, Ying-qing Feng, Xiong-Jing Jiang, Yi-Nong Jiang, Wei-Hua Li, Yan Li, Yong Li, Jinsheng Lin, Jing Liu, J. Mu, Yingxin Peng, Lei Song, N. Sun, Yan Wang, Y. Xi, Liang-di Xie, H. Xue, Jing Yu, Wei Yu, Yu-qing Zhang, Zhi-Ming Zhu   +28 more
semanticscholar   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Normal values of blood pressure self-measurement in view of the 1999 World Health Organization-International Society of Hypertension guidelines [PDF]

, 2017
New guidelines for the management of hypertension have been published in 1999 by the World Health Organization (WHO) and the International Society of Hypertension (ISH).
Düsing, R., Mengden, T., Vetter, H., Vetter, W., Weisser, B.   +4 more
core