Results 41 to 50 of about 43,257 (252)

Risk and prognosis of Omicron infection in home-based dialysis patients: a retrospective cohort study in China

BMC Nephrology
Background Home-based dialysis, including peritoneal dialysis (PD) and home hemodialysis (HHD), has been suggested to reduce SARS-CoV-2 infection rates and improve outcomes compared to in-center dialysis, yet evidence from China remains scarce. Objective
Wen Gu, Yijun Zhou, Haijiao Jin, Renhua Lu, Wei Fang, Leyi Gu, Qin Wang, Hao Yan, Xinghua Shao, Yan Fang, Zhenyuan Li, Haifen Zhang, Jiaying Huang, Aiping Gu, Jiaqi Gu, Zhaohui Ni   +15 more
doaj   +1 more source

Transforming Home Dialysis Management of Patients with Advanced Kidney Disease Using an Intelligent Automated Application in Practice

Mayo Clinic Proceedings: Digital Health, 2023
Objective: To describe the design, development, and deployment of an electronic health record (EHR)-based application to manage the Mayo Clinic home dialysis program, improve staff efficiency, and ensure delivery of high-quality clinical care.
Ziad M. Zoghby, MD, MBA, Andrea G. Kattah, MD, Kelsey Havlovic, MSN, RN, Dennis Stacy, MAN, RN, CNN, Margaret d’Uscio, APRN, CNP, DNP, Kirk P. Balderes, BS, John Seelman, BS, Karen F. Johnson, MA, John J. Dillon, MD, Alyssa Bishop, MBA, Jackie Vaughn, MA, Amy W. Williams, MD, Rajeev Chaudhry, MBBS, MPH   +12 more
doaj   +1 more source

Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation

Advanced Materials, EarlyView.
LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines, Marcus Fletcher, Manuel Bibrowski, Karnyart Samnuan, Rongjun Chen, David J. Peeler, Amjad Abouselo, Morag R. Hunter, Molly M. Stevens, Nicholas J. Brooks, Yuval Elani   +10 more
wiley   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

The WISHED Randomized Controlled Trial: Impact of an Interactive Health Communication Application on Home Dialysis Use in People With Chronic Kidney Disease

Canadian Journal of Kidney Health and Disease, 2021
Background: While home dialysis therapies are more cost effective and may offer improved health-related quality of life, uptake compared to in-center hemodialysis remains low.
Amber O. Molnar, Andrea Harvey, Michael Walsh, Arsh K. Jain, Eric Bosch, K. Scott Brimble   +5 more
doaj   +1 more source

257 Factors Associated with Primary Care Provider (PCP) Use Among Home Dialysis Patients

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: Patients utilizing dialysis receive fewer primary care services, especially during the time of initiation of dialysis. This project aims to identify clinical or demographic factors that are associated with either initiation or ...
Rohanit Singh, JiYoon Ahn, Mara McAdams Demarco, Bernard Jaar   +3 more
doaj   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Managing Transition between dialysis modalities: a call for Integrated care In Dialysis Units

Bulletin de la Dialyse à Domicile, 2022
Summary Patients with chronic kidney disease have three main possible groups of dialysis techniques: in-center hemodialysis, peritoneal dialysis, and home hemodialysis.
Bruno Fraga Dias, Anabela Rodrigues
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source