Results 61 to 70 of about 43,032 (254)

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Dialisi a casa? Sì, grazie

Giornale di Clinica Nefrologia e Dialisi, 2015
non ...
Gianna d’Adamo
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Home dialysis : what are the barriers . A French nephrologist survey

Bulletin de la Dialyse à Domicile, 2019
Home dialysis, which includes Peritoneal Dialysis and Home Hemodialysis, provides lots of profit to patients suffering of Chronic Kidney Disease, especially in terms of comfort, life quality and autonomy.
Magalie Geneviève, Stanislas Bataille, Julie Beaume, Aldjia Hocine, Louis De Laforcade, Anne-Sophie Garnier, Come Bureau, Flora Brunner, Antoine Braconnier, Guilllaume Seret   +9 more
doaj   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Fine 2014: contributi economici per la dialisi domiciliare nel Lazio

Giornale di Clinica Nefrologia e Dialisi, 2015
non ...
Gianna d’Adamo
doaj   +1 more source

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

Advanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal, Saleh Assadi, Aseem Milind Visal, Ignacio Lorente Montero, Franck J. Vernerey, Carson J. Bruns   +5 more
wiley   +1 more source

Longitudinal patterns of health-related quality of life and dialysis modality: a national cohort study

BMC Nephrology, 2019
Background Health-related quality of life (HrQoL) varies among dialysis patients. However, little is known about the association of dialysis modality with HrQoL over time.
Nwamaka D. Eneanya, Dugan W. Maddux, Marta M. Reviriego-Mendoza, John W. Larkin, Len A. Usvyat, Frank M. van der Sande, Jeroen P. Kooman, Franklin W. Maddux   +7 more
doaj   +1 more source

Community-Based Dialysis in Saskatchewan First Nations: A Grassroots Approach to Gaining Insight and Perspective From First Nations Patients With Chronic Kidney Disease

Canadian Journal of Kidney Health and Disease, 2020
Background: Renal replacement options or dialysis can be delivered in the home setting or hospital setting. Home dialysis offers a number of benefits over hospital-delivered dialysis.
Lindsay Richels, Wilson Sutherland, Kyle Prettyshield, Joanne Kappel, Michelle McCarron, Bonnie Richardson   +5 more
doaj   +1 more source