Results 41 to 50 of about 3,219,045 (305)

Early Childhood Stimulating Environment Predicts Later Childhood Resilience in an Indian Longitudinal Birth Cohort Study

open access: yesChildren, 2022
Background: Human resilience is dynamic and generated through myriad interactions starting from early childhood. Resilience can improve quality of life and longevity.
Beena Koshy   +8 more
doaj   +1 more source

HOME: Highly optimized microscope environment [PDF]

open access: yesCytometry, 1992
AbstractThe Highly Optimized Microscope Environment (HOME) is a computerized microscope designed to assist pathologists and cytotechnicians in clinical routine tasks. The prototype system consists of a IBM‐PC compatible computer and a light microscope in which a built‐in highresolution computer display image is superimposed on the optical image of the ...
G, Brugal   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tobacco consumption in the home: impact on social relationships and marking territory [PDF]

open access: yes, 2010
In this paper we move beyond viewing the home as a mere context for consumer decision-making to explore consumption practices and socio-spatial relationships within the home in relation to tobacco consumption.
Hamilton, K.L., Hassan, L.M.
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Do stimulation and support in the early childhood home environment and best friendship quality in adolescence predict adult personality?

open access: yesCurrent Issues in Personality Psychology, 2023
Background The aim of this study was to determine whether stimulation and support in early childhood and best friendship quality in adolescence predict adult personality.
Maria Wängqvist   +4 more
doaj   +1 more source

Smart Home and Artificial Intelligence as Environment for the Implementation of New Technologies [PDF]

open access: yes, 2018
The technologies of a smart home and artificial intelligence (AI) are now inextricably linked. The perception and consideration of these technologies as a single system will make it possible to significantly simplify the approach to their study, design ...
Kopytko, Vasyl   +4 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Interventions to enhance in-home taking medication among older adults with multimorbidity/polypharmacy: a systematic review and meta-analysis

open access: yesFrontiers in Public Health
IntroductionGlobal population ageing is linked to increasing multimorbidity and polypharmacy. This shift places pressure on caregivers, who often lack training and face challenges like medication mismanagement.
María Durán-Luque   +12 more
doaj   +1 more source

The role of the home environment in neurocognitive development of children in Uganda [PDF]

open access: yes, 2018
The dataset contains information on cognitive scores, home observation scores, sociodemographic information, illness history, and nutritional status of 163 5-year-old children who participated in the home-observation sub-study of the Entebbe Mother and ...
Nampijja, Margaret
core   +1 more source

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