Results 211 to 220 of about 1,756,094 (323)

Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics

Advanced Science, EarlyView.
This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu, Linling Li, Ting Luo, Gan Huang, Li Zhang, Benjamin Becker, Zhen Liang   +6 more
wiley   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Understanding the feasibility of home-based rehabilitation in kidney transplant recipients: A mixed-methods interpretation. [PDF]

PLoS One
Billany RE, Young HML, Lightfoot CJ, Bishop NC, Smith AC, Graham-Brown MPM.   +5 more
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Age and Gender Differences in Home Injury Prevention Awareness and Behaviors Among Community-Dwelling Older Adults. [PDF]

Healthcare (Basel)
Cho OH, Kim H.
europepmc   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Preferences Among U.S. Women for Cervical Cancer Screening with Self-Collected Specimens for Human Papillomavirus Testing. [PDF]

Obstet Gynecol
Qin J, Martinez G, Holt HK, Gopalani SV, Trivers KF, Miller JW, Senkomago V, Sawaya GF.   +7 more
europepmc   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Dual‐Array Nano Configuration for High‐Performance Metastable β Titanium Alloys

Advanced Science, EarlyView.
This work resolves a fundamental paradox in metastable alloys by establishing a novel dislocation‐phase coupling mechanism, enabling dynamic microstructure control for simultaneous thermal stability and deformability. Geometrically ordered α‐nanograins achieve unprecedented 500°C strength‐ductility synergy (863 MPa UTS, 78.3% elongation).
Tianle Li, Renhao Wu, Jiabao Liu, Sang‐Ho Oh, Xiang Wu, Hyojin Park, Byeong‐Joo Lee, Hidemi Kato, Hyoung Seop Kim, Xiaochun Liu, Xifeng Li   +10 more
wiley   +1 more source

Hospital-at-Home for South Asian Communities in British Columbia, Canada: Qualitative Interview Study.

JMIR Hum Factors
Wong E, Kandola M, Arora K, Sharda H, Deol R, Jung M, Paquin R, Montenegro M, MacPherson M.   +8 more
europepmc   +1 more source