Results 41 to 50 of about 2,823,356 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efficacy and safety of a combination antihypertensive drug (olmesartan plus azelnidipine): “Issues with hypertension studies in real-world practice”

Clinical and Experimental Hypertension, 2020
Background: This study investigated whether a combination drug containing an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) could provide effective antihypertensive therapy. Methods: A multicenter, prospective, open-label study
Keisuke Okamura, Yuiko Yano, Yosuke Takamiya, Kazuyuki Shirai, Hidenori Urata   +4 more
doaj   +1 more source

Increasing the voluntary and community sector’s involvement in Integrated Offender Management(IOM) [PDF]

, 2011
As part of an undertaking to increase voluntary and community sector (VCS) involvement in service delivery, the Home Office set up an initiative to provide small grants to VCS organisations to work with IOM partnerships.
Bird, Hayden, Davidson, Joanna, Meadows, Linda, O'Keeffe, Caroline, Senior, Paul, Wilkinson, Katherine, Wong, Kevin   +6 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Adult Social Work and High Risk Domestic Violence Cases [PDF]

, 2018
Summary This article focuses on adult social work’s response in England to high-risk domestic violence cases and the role of adult social workers in Multi-Agency Risk and Assessment Conferences. (MARACs).
Blood I., Claire Bellamy, Concetta Banks, Cresswell J. W., Debbie Thackray, Department of Health (DH), Flatley J., FRA (European Union agency for Fundamental Rights), Harne L., Home Office, Home Office, Home Office, House of Commons Home Affairs Committee, Howarth E., Hugh McLaughlin, Lazenbatt A., LGA, Pritchard J., Punch K. F., Rachel Robbins, Scott M., Sheldon B., World Health Organization (WHO)   +22 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Coping Stress Differences among Work from Home and Work from Office Individuals

Philanthropy: Journal of Psychology
. Working from home and working permanently in the office (work from office) have their problems. These differences indeed lead to different responses in coping with stress.
Arri Handayani, Desi Maulia, Padmi Dhyah Yulianti, Primaningrum Dian   +3 more
doaj   +1 more source

Sustained Work from Home Post-Pandemic? A Swedish Case

Findings, 2023
We investigate whether office workers will continue to work from home after COVID-19 pandemic restrictions. Office workers at Swedish public agencies were surveyed concerning the pre-pandemic experience of work from home, current practices, and ...
Bertil Vilhelmson, Eva Thulin, Louise Brundin   +2 more
doaj   +1 more source

Response to the Home Office Consultation (2006) on 'Making Sentencing Clearer' [PDF]

, 2007
This is the response of Dr Easton and Professor Piper to the Consulation Paper, 'Making Sentencing Clearer' published by the Home Office in 2006. The deadline for responses was 9 January 2007 and a summary of responses will be published on the Home ...
Easton, S, Piper, CD
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source