Results 51 to 60 of about 4,440,878 (245)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Efficacy and safety of a combination antihypertensive drug (olmesartan plus azelnidipine): “Issues with hypertension studies in real-world practice”

Clinical and Experimental Hypertension, 2020
Background: This study investigated whether a combination drug containing an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) could provide effective antihypertensive therapy. Methods: A multicenter, prospective, open-label study
Keisuke Okamura, Yuiko Yano, Yosuke Takamiya, Kazuyuki Shirai, Hidenori Urata   +4 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Daily use of self-leadership strategies and employee work engagement while working from home and the office

Scientific Reports
Employees’ work engagement may vary by work location (office vs. home office), assuming that working at home requires greater self-regulation. Hence, self-leadership may play an important role when employees work at home.
Ada Sil Patterer, Anita C. Keller, Katharina Woharcik, Jana Kühnel   +3 more
doaj   +1 more source

The Associations of Sedentary Behaviour and Physical Activity With Musculoskeletal Disorders in Hybrid-Office Workers: A Compositional Data Analysis

Baltic Journal of Sport and Health Sciences
Purpose: The aims of the present study are (1) to examine sedentary behaviour and physical activity patterns in hybrid-office workers in home and office contexts, and (2) to assess the associations of such activity patterns with musculoskeletal symptoms.
Iris Parés-Salomón, Alan Coffey, Bette Loef, Kieran P. Dowd, Eva Cirera Viñolas, Anna M. Señé Mir, Arnau Gustems Morral, Maja Pajek, Karin I. Proper, Anna Puig-Ribera, Judit Bort-Roig   +10 more
doaj   +1 more source

Home Office Fingerprint Source Book [PDF]

, 2018
The Fingerprint Source Book is primarily intended to provide the background and validation for the techniques currently (up to 2016) recommended by the Home Office Centre for Applied Science and Technology (CAST), and to publish, in some cases for the ...
Bandey, H, Bowman, V, Downham, R, Ramadani, J, Bleay, S, Sears, V, Selway, C, Ciuksza, T, Gibson, A   +8 more
core  

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

The architectural dimension of teleworking [PDF]

Urbani Izziv, 2005
The computer has become an integral part of our environment. With the integration of information and communication technologies into the working process the organization of office work is rapidly changing, influencing the office spaces as well as office ...
Iztok Kovačič
doaj  

The impact of home office on employee productivity and work balance [PDF]

Problems and Perspectives in Management
The implementation of the home office has changed the organization of work not only during the pandemic but also permanently, so it is considered challenging to explore the effects on work processes and the value orientation of employees. This study aims
Adriana Grenčíková, Jana Španková, Marcel Kordoš   +2 more
doaj   +1 more source