Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Space Use by Brown Bears (Ursus arctos) in the Sikhote-Alin [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2019 Proper management of brown bear populations (Ursus arctos) requires knowledge of their ecology, including space use. Brown bear spatial patterns are particularly poorly understood in the Russian Far East, due to lack of telemetry studies. The aim of this
Ivan V. Seryodkin +3 more
doaj +1 more source
The home range of the signal crayfish in a British lowland river [PDF]
, 1997 The signal crayfish Pacifastacus leniusculus (Dana), a native of north-western North America, is now a common resident in some British fresh waters following its introduction to England in 1976 (Lowery & Holdich 1988).
Guan, Rui-Zhang, Wiles, Peter
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Seasonal variation in the ranging behavior of elephants in the Laikipia‐Samburu ecosystem
Ecology and EvolutionAfrican savanna elephants are a highly mobile species that ranges widely across the diversity of ecosystems they inhabit. In xeric environments, elephant movement patterns are largely dictated by the availability of water and suitable forage resources ...
Loise W. Kuria +4 more
doaj +1 more source
Development and trial of a methodology for the quantification and evaluation of home composting in Palmerston North, New Zealand : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Environmental Management (without major) at Massey University, Palmerston North, New Zealand [PDF]
, 2017 Home composting and commercial composting can be regarded as part of the Municipal Solid Waste Management system. Currently, in Palmerston North and more broadly in New Zealand, home composting plays an important, but an unquantified role in waste ...
Mensah, Sabina
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Selection on fish personality differs between a no‐take marine reserve and fished areas
Evolutionary Applications, 2021 Marine reserves can protect fish populations by increasing abundance and body size, but less is known about the effect of protection on fish behaviour. We looked for individual consistency in movement behaviours of sea trout in the marine habitat using ...
Susanna Huneide Thorbjørnsen +5 more
doaj +1 more source
The impact of fire on habitat use by the short-snouted elephant shrew ('Elephantulus brachyrhynchus') in North West Province, South Africa [PDF]
, 2008 Several studies have investigated the response of small mammal populations to fire, but few have investigated behavioural responses to habitat modification. In this study we investigated the impact of fire on home range, habitat use and activity patterns
ARNOLD +46 more
core +1 more source