Results 51 to 60 of about 10,920,655 (288)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Seasonal variation in the ranging behavior of elephants in the Laikipia‐Samburu ecosystem

Ecology and Evolution
African savanna elephants are a highly mobile species that ranges widely across the diversity of ecosystems they inhabit. In xeric environments, elephant movement patterns are largely dictated by the availability of water and suitable forage resources ...
Loise W. Kuria, Duncan M. Kimuyu, Mwangi J. Kinyanjui, George Wittemyer, Festus W. Ihwagi   +4 more
doaj   +1 more source

Drivers of habitat quality for a reintroduced elk herd

Scientific Reports, 2022
Understanding spatiotemporal variation in habitat quality is essential for guiding wildlife reintroduction and restoration programs. The habitat productivity hypothesis posits that home range size is inversely related to habitat quality. Thus, home range
Braiden A. Quinlan, Jacalyn P. Rosenberger, David M. Kalb, Heather N. Abernathy, Emily D. Thorne, W. Mark Ford, Michael J. Cherry   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Correlates of home range sizes of giraffes, Giraffa camelopardalis [PDF]

Animal Behaviour, 2019
Abiotic, biotic and human influences are factors that can affect animal home ranges. We calculated home range sizes of adult giraffes in the Tarangire-Manyara region of northern Tanzania (N = 132 giraffes with data collected over 6 years), and investigated correlations between home range sizes and environmental and anthropogenic factors (for a subset ...
Knüsel, Mara A, Lee, Derek E, König, Barbara, Bond, Monica L   +3 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Estimated breeding season home range size.

, 2016
Estimated home range size of 2011 nonbreeders was significantly larger than range size of 2012 breeders. The estimated home range size for the three 2012 nonbreeders are included as X’s on the graph, but due to low sample size, were not included in ...
Taza D. Schaming (738127)
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

How resource abundance and resource stochasticity affect organisms’ range sizes

Movement Ecology
Background From megafauna to amoebas, the amount of space heterotrophic organisms use is thought to be tightly linked to the availability of resources within their habitats, such that organisms living in productive habitats generally require less space ...
Stefano Mezzini, Christen H. Fleming, E. Patrícia Medici, Michael J. Noonan   +3 more
doaj   +1 more source

Bald Eagle home range size and core-use areas in an urbanizing landscape

Global Ecology and Conservation
Urbanization has contributed to the decline of many wildlife species through habitat loss. To examine how Bald Eagles (Haliaeetus leucocephalus) respond to urbanization we used dynamic Brownian bridge movement models to estimate home range size and core ...
Miranda Middleton, Reesa Yale Conrey, Nicolas Jaffe, Liba Pejchar   +3 more
doaj   +1 more source