Results 71 to 80 of about 2,427,133 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Site Fidelity in Space Use by Spider Monkeys (Ateles geoffroyi) in the Yucatan Peninsula, Mexico [PDF]

, 2013
Animal home ranges may vary little in their size and location in the short term but nevertheless show more variability in the long term. We evaluated the degree of site fidelity of two groups of spider monkeys (Ateles geoffroyi) over a 10- and 13-year ...
A Valero, B Van Moorter, BJ Worton, BJ Worton, CA Peres, CH Janson, CM Schaffner, Colleen M. Schaffner, D Topping, DP Watts, E Garcia-Frapolli, EF Connor, EK Bollinger, F Michalski, Filippo Aureli, FM van Beest, FM Wartmann, G Ramos-Fernandez, G Ramos-Fernandez, G Ramos-Fernandez, Gabriel Ramos-Fernandez, JG Kie, KI Hanski, KRL Janmaat, L Börger, L Börger, L Börger, Laura G. Vick, M Mcfarland Symington, MA Cairns, MM Symington, MR Symonds, N Asensio, N Asensio, PD Mcloughlin, PN Laver, PV Switzer, PW Lurz, RB Wallace, RB Wallace, S Blake, SA Suarez, Sandra E. Smith Aguilar, Sharon Gursky-Doyen, SN Spehar, SollaSR De, U Radespiel, W Jetz, WH Burt, WM Getz, WM Getz, YK Ortega   +51 more
core   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Urbanisation influences range size of the domestic cat (Felis catus): consequences for conservation [PDF]

, 2017
Domestic cats (Felis catus) are the most abundant predator in many urban ecosystems, and their ranging behaviour will help determine predation rates. To investigate how degree of urbanisation affects cat ranging behaviour, we used GPS trackers to follow ...
Fellowes, Mark D. E., Hanmer, Hugh J., Thomas, Rebecca L.   +2 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Home Range of Lomas Lizard Microlophus tigris (Sauria: Tropiduridae) in Carabayllo Lomas, Lima - Peru

Revista Peruana de Biología, 2017
The home range is the area where an individual finds the resources for its survival; therefore, the home range studies of organisms are fundamental to know their ecology and conservation status. The Loma’s lizard, Microlophus tigris is an endemic species
Jorge Ruiz S., Karina Junes, José Pérez Z.   +2 more
doaj   +1 more source

Spatial ecology of the critically endangered Fijian crested iguana, Brachylophus vitiensis, in an extremely dense population: implications for conservation

, 2015
The Critically Endangered Fijian crested iguana, Brachylophus vitiensis, occurs at extreme density at only one location, with estimates of >10,000 iguanas living on the 70 hectare island of Yadua Taba in Fiji. We conducted a mark and recapture study over
Biciloa, Pita, Harlow, Peter S., Keogh, J. Scott, Morrison, Suzanne F.   +3 more
core   +1 more source

Dynamics of direct inter-pack encounters in endangered African wild dogs [PDF]

, 2017
Aggressive encounters may have important life history consequences due to the potential for injury and death, disease transmission, dispersal opportunities or exclusion from key areas of the home range.
A Mosser, AC Markham, Alan M Wilson, AM Wilson, AN Radford, ASAB/ABS, C Calenge, C Sillero-Zubiri, CE Grueber, Christopher Buse, D Bates, DL Cheney, DM Kitchen, DM Kitchen, DM Kitchen, F Koch, J Weldon McNutt, JA Drewe, JL Rachlow, JM Shopland, JM Smith, John C Lowe, JP Rood, JW McNutt, K Barton, K McComb, KA Cassidy, Krystyna A Golabek, LD Mech, Leanne K Van der Weyde, LS Ewing, M Cant, MA Pomilia, ME Craft, MG Mills, ML Wilson, Neil R Jordan, P Sicotte, Peter J Apps, PW Kat, R Woodroffe, R Woodroffe, RD Furrer, S Creel, S Creel, SA Osofsky, SW Townsend, TY Hubel, TY Hubel, WJ Hamilton, WJ Hamilton   +50 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Factors shaping home ranges of Eurasian lynx (Lynx lynx) in the Western Carpathians

Scientific Reports
Understanding how large carnivores utilize space is crucial for management planning in human-dominated landscape and enhances the accuracy of population size estimates. However, Eurasian lynx display a large inter-population variation in the size of home
Jakub Kubala, Johannes Signer, Slavomír Finďo, Martin Duľa, Jarmila Krojerová-Prokešová, Robert W. Mysłajek, Sabina Nowak, Jozef Bučko, Michaela Skuban, Miroslav Kutal, Michal Bojda, Jiří Labuda, Michał Figura, Miroslava Barančeková, Miloslav Homolka, Petr Koubek, Marián Slamka, Branislav Tám, Michal Belák, Tomáš Iľko, Beňadik Machciník, Peter Klinga, Maroš Sedliak, Rudolf Kropil, Peter Smolko   +24 more
doaj   +1 more source