Results 271 to 280 of about 3,024,874 (379)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Metal homeostasis as a therapeutic lever: advancing metalloimmunology to remodel the tumor microenvironment and enhance cancer immunotherapy. [PDF]

Theranostics
Chen X, Wang Q, Zhang H, Wang Y, Zhu H.
europepmc   +1 more source

Vitamin E-Mediated Modulation of Pulmonary Toxicity and Mineral Homeostasis in Experimental Rats Exposed to Crude Oil Vapor

Oyeyemi Adeyemi, Oluwafemi Oluwafemi, Offor C. E   +2 more
openalex   +2 more sources

Erratum for Attarian et al., “The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans”

, 2019
Rodgoun Attarian, Guanggan Hu, Eddy Sánchez‐León, Mélissa Caza, Daniel Croll, Eunsoo Do, Horacio Bach, Tricia A. Missall, Jennifer K. Lodge, Won Hee Jung, James W. Kronstad   +10 more
openalex   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Commensal bacteria play a fundamental role in maintaining gut immune homeostasis. [PDF]

J Zhejiang Univ Sci B
Tu S, Zhang Y, Zhang L, Zhu SJ.
europepmc   +1 more source

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

Cell, 2019
Ninib Baryawno, Dariusz Przybylski, Monika S. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, Konstantinos D. Kokkaliaris, F. Mercier, M. Tabaka, Matan Hofree, Danielle Dionne, Ani Papazian, Dongjun Lee, O. Ashenberg, Ayshwarya Subramanian, E. D. Vaishnav, O. Rozenblatt-Rosen, A. Regev, D. Scadden   +18 more
semanticscholar   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications. [PDF]

Ann Med
Li Y, Lu Y, Lin X, Zhao L.
europepmc   +1 more source

Incorporation of Unique, Diet-derived Fatty Acids into Hepatic Tissue Is Associated with Improved Glucose Homeostasis in Aged CD-1 Mice (OR24-02-19)

, 2019
Allison L. Unger, Thomas L. Jetton, J. R. Whitley, Jana Kraft   +3 more
openalex   +1 more source