Results 71 to 80 of about 210,246 (333)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Current Perspectives on Role of MSC in Renal Pathophysiology
Frontiers in Physiology, 2018 In the course of the development and worsening of kidney disease, the treatments available are expensive and may cause adverse effects such as immune rejection, inadequate renal resources, or post-operative complications. Therefore, there is an urgent to
Min Fan +4 more
doaj +1 more source
Must-Take Cards: Merchant Discounts and Avoided Costs [PDF]
, 2011 Antitrust authorities often argue that merchants cannot reasonably turn down payment cards and therefore must accept excessively high merchant discounts. The paper attempts to shed light on this “must-take cards” view from two angles.
ROCHET, Jean Charles, TIROLE, Jean
core +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Influência da infecção no lactente na expressão de quimiocinas e de seus receptores envolvidos no homing de leucócitos para o leite materno [PDF]
, 2020 Yingying Zheng
openalex +1 more source
Ferromagnetic material in the eastern red-spotted newt notophthalmus viridescens [PDF]
, 1999 Behavioral results obtained from the eastern red-spotted newt (Notophthalmus viridescens) led to the suggestion of a hybrid homing system involving inputs from both a light-dependent and a non-light-dependent mechanism. To evaluate the possible role of a
Borland, S. C. +3 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Ecology and Evolution, 2019 The anadromous salmon life cycle includes two migratory events, downstream smolt migration and adult homing migration, during which they must navigate with high precision.
Steffen S. Madsen +4 more
doaj +1 more source