Results 61 to 70 of about 61,248 (347)
Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]
, 2012 Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Aschenbrenner, Frank +8 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal for ImmunoTherapy of Cancer, 2019 Background The peculiar multiple myeloma microenvironment, characterized by up-regulated levels of several inflammatory chemokines, including the CXCR3 receptor ligands CXCL9 and CXCL10, limits NK cell positioning into the bone marrow by interfering with
Valentina Bonanni +3 more
doaj +1 more source
Methylphenidate Treatment and Home Behavior
Pediatric Neurology Briefs, 1997 Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate are reported in a study of 91 children receiving MPH (titrated to 0.7 mg/kg twice a day) or placebo for 4 months at the Hospital for Sick Children, Toronto, Canada.
openaire +3 more sources
Behavioral Determinants of Home Bias - Theory and Experiment [PDF]
SSRN Electronic Journal, 2014 We study portfolio diversification in an experimental decision task, where asset returns depend on a draw from an ambiguous urn. Holding other information identical and controlling for the level of ambiguity, we find that labeling assets as being familiar or from the homeland of subjects increases portfolio weights by around 25%, respectively; although
Dennis Dlugosch, Kristian Horn, Mei Wang
openaire +3 more sources
A weighted pair graph representation for reconstructibility of Boolean control networks [PDF]
, 2016 A new concept of weighted pair graphs (WPGs) is proposed to represent a new reconstructibility definition for Boolean control networks (BCNs), which is a generalization of the reconstructibility definition given in [Fornasini & Valcher, TAC2013, Def. 4].
Su, Rong, Zhang, Kuize, Zhang, Lijun
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Scientific ReportsBees are often exposed to pesticides affecting physiological functions and molecular mechanisms. Studies showed a potential link between altered expression of energy metabolism related transcripts and increased homing flight time of foragers exposed to ...
Anna Keodara +5 more
doaj +1 more source
Spatiotemporal structure of foraging and path integration errors by fiddler crabs, Leptuca pugilator
Frontiers in Marine SciencePath integration is the navigational process by which animals construct a memory of a previous location by continuously measuring and summing their movements to form a single home vector pointing to the starting location. It is intrinsically error prone,
Ruma Chatterji, John E. Layne
doaj +1 more source
Respiration and Heart Rate at the Surface between Dives in Northern Elephant Seals [PDF]
, 2000 All underwater activities of diving mammals are constrained by the need for surface gas exchange. Our aim was to measure respiratory rate (fb) and heart rate (fh) at the surface between dives in free-ranging northern elephant seals Mirounga ...
Blackwell, Susanna B. +6 more
core +1 more source