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Natural killer cell homing and trafficking in tissues and tumors: from biology to application [PDF]
Signal Transduction and Targeted Therapy, 2022 Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK cells can develop in secondary lymphoid tissues, NK cells develop mainly in the bone marrow (BM) and ...
Guang he Ran +6 more
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Homing in on the Sweet Side of Immune Checkpoint Biology [PDF]
Immunity, 2016 P-selectin glycoprotein ligand-1 (PSGL-1) and its glycostructural determinants facilitate responses to infection and cancer by promoting immune effector-cell trafficking into inflamed tissue. In this issue of Immunity, Tinoco et al. (2016) report homing-independent functions of PSGL-1 in immune checkpoint regulation and T cell effector activity, in ...
Steven R. Barthel, Tobias Schatton
semanticscholar +4 more sources
Hematopoietic stem cell homing: biology and clinical prospectives
Translational MedicineThe hematopoietic stem cell (HSC) niche is a specific microenvironment in the bone marrow that maintains the ability of HSCs to differentiate and self-renew. It comprises two interconnected sub-niches: the vascular and the intraosseous. This distinction is particularly relevant in the context of homing, as hematopoietic stem cells sequentially interact
D. A. Protasov, Pavel Butylin
semanticscholar +4 more sources
Current Understanding of Extracellular Vesicle Homing/Tropism
Zoonoses, 2022 Extracellular vesicles (EVs) are membrane-enclosed packets that are released from cells and subsequently transfer bioactive molecules between cells without directly contacting the target cells.
Mariola J. Edelmann, Peter E. Kima
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Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
Frontiers in Immunology, 2014 Fatty acids are involved in T cell biology both as nutrients important for energy production as well as signalling molecules. In particular, polyunsaturated fatty acids are known to exhibit a range of immunomodulatory properties that progress through T ...
Anna eNicolaou +3 more
doaj +5 more sources
Olfaction Contributes to Pelagic Navigation in a Coastal Shark. [PDF]
, 2016 How animals navigate the constantly moving and visually uniform pelagic realm, often along straight paths between distant sites, is an enduring mystery. The mechanisms enabling pelagic navigation in cartilaginous fishes are particularly understudied.
Chai, Fei +4 more
core +18 more sources
Cell Chemical Biology: Home of Exciting Chemical Biology [PDF]
Cell Chemical Biology, 2016 Table of Content Wish List“An Atomic Resolution Map of a Working Cell” (Bridget Carragher)“A Universal Method for Compound Target Identification” (James K. Chen)“A Lego Kit of Biosynthetic Modules for Secondary Metabolite Production” (James K. Chen)“Quantitative Sequencing of Carbohydrate Modifications on Proteins” (James K.
Kostic, M +4 more
openaire +4 more sources
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion. [PDF]
PLoS ONE, 2012 BACKGROUND: Expansion of hematopoietic stem/progenitor cells (HSPCs) is a well-known strategy employed to facilitate the transplantation outcome. We have previously shown that the prevention of apoptosis by the inhibition of cysteine proteases, caspase ...
V M Sangeetha +3 more
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Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. [PDF]
PLoS ONE, 2006 Biomedical researchers have become increasingly aware of the limitations of conventional 2-dimensional tissue cell culture systems, including coated Petri dishes, multi-well plates and slides, to fully address many critical issues in cell biology, cancer
Fabrizio Gelain +3 more
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Pharmaceutics, 2023 Extracellular vesicles (EVs) are a heterogeneous class of cell-derived membrane vesicles released by various cell types that serve as mediators of intercellular signaling.
Debora Petroni +5 more
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