Rapidly evolving homing CRISPR barcodes
Nature Methods, 2016 We present an approach for engineering evolving DNA barcodes in living cells. A homing guide RNA (hgRNA) scaffold directs the Cas9–hgRNA complex to the DNA locus of the hgRNA itself.
Reza Kalhor, P. Mali, G. Church
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Exaptation and emergence as mechanisms to cross fitness valleys during evolution: an example using simulated homing behaviour [PDF]
, 2008 Evolution is often considered a gradual hill climbing process, slowly increasing the fitness of organisms. I investigate the evolution of homing behaviour in simulated intertidal limpets.
Richard Stafford
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T-cell help in the germinal center: homing in on the role of IL-21
International ImmunologyInterleukin 21 (IL-21) is a pleiotropic cytokine that is overproduced in multiple autoimmune settings. Provision of IL-21 from follicular helper T cells is an important component of T-cell help within germinal centers (GC), and the last few years have ...
L. Petersone, Lucy S K Walker
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Head-mounted sensors reveal visual attention of free-flying homing pigeons
Journal of Experimental Biology, 2018 Gaze behavior offers valuable insights into attention and cognition. However, technological limitations have prevented the examination of animals' gaze behavior in natural, information-rich contexts; for example, during navigation through complex ...
Fumihiro Kano +3 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Diversity of Pneumocystis jirovecii during infection revealed by ultra-deep pyrosequencing
Frontiers in Microbiology, 2016 Pneumocystis jirovecii is an uncultivable fungal pathogen responsible for Pneumocystis pneumonia (PcP) in immunocompromised patients, the physiopathology of which is only partially understood.
Alexandre eAlanio +12 more
doaj +1 more source
Ferromagnetic material in the eastern red-spotted newt notophthalmus viridescens [PDF]
, 1999 Behavioral results obtained from the eastern red-spotted newt (Notophthalmus viridescens) led to the suggestion of a hybrid homing system involving inputs from both a light-dependent and a non-light-dependent mechanism. To evaluate the possible role of a
Borland, S. C. +3 more
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The magnetite-based receptors in the beak of birds and their role in avian navigation [PDF]
, 2012 Iron-rich structures have been described in the beak of homing pigeons, chickens and several species of migratory birds and interpreted as magnetoreceptors.
Wiltschko, Roswitha, Wiltschko, Wolfgang
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