Results 191 to 200 of about 1,477,310 (345)

Homo Sapiens, Homo Curans

open access: yesPrometeica - Revista de Filosofía y Ciencias
En este artículo, me propongo mostrar cómo el acto de cuidar está esencialmente atravesado por significados biológicos, psicológicos, sociales y morales. Esto lo convierte en un núcleo teórico sobre el cual es posible desarrollar un enfoque moderadamente naturalista, pero filosóficamente relevante y significativo.
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Genetic and epidemiological patterns of primary immunodeficiency diseases in Eastern Iranian patients. [PDF]

open access: yesSci Rep
Salehi M   +6 more
europepmc   +1 more source

Replication data for: Palaeoecological context of Homo aff. erectus (ATE7-1) at Sima del Elefante (late Early Pleistocene, Atapuerca, Spain), inferred from the herpetofaunal assemblage

open access: green
Sánchez-Bandera, Christian   +10 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Symmetrical D-π-A-π-D indanone dyes: a new design for nonlinear optics and cyanide detection. [PDF]

open access: yesBeilstein J Org Chem
Keleş E   +4 more
europepmc   +1 more source

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