Results 221 to 230 of about 703,597 (255)

Sex differences in the pathogenesis of degenerative knee osteoarthritis: a comparative transcriptomics analysis. [PDF]

Front Aging
Ogunsola AS, Brady DJ, Foster JA, Brown MG, Hartzler MA, Langfitt MK, Shields JS, Ma X.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Accelerating Electrolyte Discovery Using Generative Models and Molecular Dynamics Simulations. [PDF]

ACS Omega
Deerattrakul V, Duangdangchote S, Boonchun A, Iamprasertkun P.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Interfacial Potential Compensation for HOMO Alignment in Ternary Organic Solar Cells. [PDF]

Small
Gao Z, Li W, Liu H, Li X, Zhang Q, Liu T, Li H, Liu X, Yu L, Bao X, Xu X, Ding L, McCulloch I, Lu X, Fahlman M, Wang C.   +15 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

CO₂ Activation by Small Copper, Cobalt, and Yttrium Oxide Clusters Probed via Infrared Multiple-Photon Dissociation Spectroscopy. [PDF]

Chemphyschem
Mikolaj P, Bakker JM, Lang SM.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing. [PDF]

Neurotherapeutics
Liu Y, Qu HQ, Mentch FD, Chang X, Kim J, Qiu H, Ostberg K, Nguyen K, Glessner J, Hakonarson H.   +9 more
europepmc   +1 more source

Mechanism of SLC15A3 Regulating Macrophage Oxidative Stress in the Pathogenesis of Traumatic Tracheal Stenosis. [PDF]

J Inflamm Res
Huang L, Chen J, Tan S, Qin Y, Liu G.
europepmc   +1 more source