Results 131 to 140 of about 214,984 (288)

Exploring the Boundaries of Aromaticity in Complex Structures and Excited States Through Computational Analysis

Chemistry – A European Journal, EarlyView.
Understanding aromaticity has evolved from benzene‐centric concepts to a broad multidimensional framework spanning organic, inorganic, and excited‐state systems. This review highlights ambiguities between magnetic, electronic, geometric, and energetic descriptors, emphasizing the need for unified, multi‐criteria approaches.
Sílvia Escayola, Miquel Solà, Albert Poater   +2 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley   +1 more source

Digital human modelling - Quo vadis, Homo Sapiens Digitalis? [PDF]

Z Arbeitswiss, 2022
Fritzsche L, Bengler K, Spitzhirn M.
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Lithic Miniaturization Provides a Signature of an MIS4-3 Southern Dispersal of Homo sapiens. [PDF]

Evol Anthropol
Shipton C.
europepmc   +1 more source

Substantial light woodland and open vegetation characterized the temperate forest biome before Homo sapiens. [PDF]

Sci Adv, 2023
Pearce EA, Mazier F, Normand S, Fyfe R, Andrieu V, Bakels C, Balwierz Z, Bińka K, Boreham S, Borisova OK, Brostrom A, de Beaulieu JL, Gao C, González-Sampériz P, Granoszewski W, Hrynowiecka A, Kołaczek P, Kuneš P, Magri D, Malkiewicz M, Mighall T, Milner AM, Möller P, Nita M, Noryśkiewicz B, Pidek IA, Reille M, Robertsson AM, Salonen JS, Schläfli P, Schokker J, Scussolini P, Šeirienė V, Strahl J, Urban B, Winter H, Svenning JC.   +36 more
europepmc   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

The emergence of homo sapiens sapiens

, 2009
Invited single-authored chapter in a volume edited by Cunliffe, Gosden & Joyce (2009), exploring the evidence for the development and spread of Homo sapiens sapiens throughout the Old World between 200 and 20 thousand years ago.
Davies, William
core   +1 more source

Quantitative Study of Elbow Ligaments in Modern Humans (Homo sapiens) and Common Chimpanzees (Pan troglodytes). [PDF]

Am J Biol Anthropol
Potau JM, Casado A, Rodríguez P, García-Cuesta M, Ciurana N, de Paz FJ, Barbosa M, José IJS, Cabo R, Pastor JF.   +9 more
europepmc   +1 more source