Results 51 to 60 of about 360,376 (378)

Early evidence of stone tool use in bone working activities at Qesem Cave, Israel [PDF]

, 2016
For a long while, the controversy surrounding several bone tools coming from pre-Upper Palaeolithic contexts favoured the view of Homo sapiens as the only species of the genus Homo capable of modifying animal bones into specialised tools.
Barkai, Ran, Blasco, Ruth, CRISTIANI, Emanuela, Gopher, Avi, LEMORINI, Cristina, Nunziante Cesaro, Stella, Rosell, Jordi, VENDITTI, FLAVIA, Zupancich, Andrea   +8 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

EEG Dataset for RSVP and P300 Speller Brain-Computer Interfaces

Scientific Data, 2022
Measurement(s) Electroencephalography Technology Type(s) electroencephalography (EEG) Sample Characteristic - Organism Homo ...
Kyungho Won, Moonyoung Kwon, Minkyu Ahn, Sung Chan Jun   +3 more
doaj   +1 more source

Toward a psychology of Homo sapiens: Making psychological science more representative of the human population

Proceedings of the National Academy of Sciences of the United States of America, 2018
Two primary goals of psychological science should be to understand what aspects of human psychology are universal and the way that context and culture produce variability.
Mostafa Salari Rad, Alison Jane Martingano, Jeremy Ginges   +2 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Homo sapiens: cancer or parasite?

Ethics in Science and Environmental Politics, 2014
Two contrasting ideas, that humans are ‘part of the ecosystem’ (i.e. a constitutive element of the ecosystems they exploit) and that humans are ‘a cancer on the Earth’, are examined in the light of the current despoliation of the biosphere.
D Pauly
doaj   +1 more source

Homo economicus vs homo sapiens? [PDF]

, 2018
La crisi va ser la demostració incontestable que la recerca del benefici propi és una de les motivacions fonamentals de l'ésser humà en molts contextos, i especialment en els mercats. Significa això que l'homo sapiens és un homo economicus?
Cubel, Maria, Sánchez-Pagés, Santiago
core  

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source