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Homocysteine and atherosclerosis
Current Opinion in Lipidology, 1999Elevated plasma total homocysteine is an independent risk factor for atherosclerotic vascular disease. Risk rises continuously across the spectrum of homocysteine concentrations and may become appreciable at levels greater than 10 mumol/l. A compelling case can be made for screening all individuals with atherosclerotic disease or at high risk.
G T, Gerhard, P B, Duell
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2011
The aim of this review is to evaluate the evidence for and against fasting plasma total homocysteine (tHcy) as a biomarker/risk factor of impaired reproductive function before and during pregnancy. Apart from nutritional and lifestyle factors, tHcy is also influenced by physiological factors specific to pregnancy such as hemodilution, increased ...
Michelle M, Murphy +1 more
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The aim of this review is to evaluate the evidence for and against fasting plasma total homocysteine (tHcy) as a biomarker/risk factor of impaired reproductive function before and during pregnancy. Apart from nutritional and lifestyle factors, tHcy is also influenced by physiological factors specific to pregnancy such as hemodilution, increased ...
Michelle M, Murphy +1 more
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The Lancet, 2001
During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic stroke because of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium.
G J, Hankey, J W, Eikelboom
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During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic stroke because of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium.
G J, Hankey, J W, Eikelboom
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Homocysteine and Atherothrombosis
New England Journal of Medicine, 1998In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease.1 He reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocystinuria.
G N, Welch, J, Loscalzo
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New England Journal of Medicine, 2002
Homocysteine is a simple amino acid that has recently received a great deal of attention as a risk factor for atherothrombotic vascular disease. There is reasonably compelling epidemiologic evidence of an association between the plasma homocysteine level and the risk of vascular disease in the coronary, carotid, and peripheral circulations.
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Homocysteine is a simple amino acid that has recently received a great deal of attention as a risk factor for atherothrombotic vascular disease. There is reasonably compelling epidemiologic evidence of an association between the plasma homocysteine level and the risk of vascular disease in the coronary, carotid, and peripheral circulations.
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Homocysteine-induced thrombosis
British Journal of Biomedical Science, 2004The connection between homocysteine and thrombosis was identified approximately 25 years ago when it was reported that people with a rare condition called homocystinuria accumulated homocysteine in the blood and excreted it in the urine. Recent studies provide overriding evidence to suggest that elevated blood homocysteine levels can cause thrombosis ...
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2003
Homocysteine is an amino acid that is involved in several key metabolic processes, including the methylation and sulphuration pathways. Blood concentrations of homocysteine are determined by various dietary factors, including folic acid and vitamin B(12), by alteration in physiology, such as renal impairment, and by variation in the activity of enzymes
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Homocysteine is an amino acid that is involved in several key metabolic processes, including the methylation and sulphuration pathways. Blood concentrations of homocysteine are determined by various dietary factors, including folic acid and vitamin B(12), by alteration in physiology, such as renal impairment, and by variation in the activity of enzymes
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Homocystein – Ist die Homocystein-These tot?
Erfahrungsheilkunde, 2010Some years ago, scientists discovered that homocysteine in the blood is a cardiovascular risk factor. This has been confirmed by fundamental experiments and epidemiologic studies. The studies HOPE-2 and NORVIT seem to have refuted the thesis. A critical analysis of the examinations suggests, that a lowering of the homocysteine value with vitamin B ...
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