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DNA Methylation change in genes involved in Alcohol metabolism (ALDH2) and One-carbon metabolism (MTHFR) pathways among people with Alcohol Use Disorder

Shankarappa B, Mahadevan J, Viswanath B, Devarbhavi H, Murthy P, Jain S, Purushottam M.   +6 more
europepmc   +1 more source

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Homocysteine

Critical Reviews in Clinical Laboratory Sciences, 1999
Homocysteine is a sulfur-containing amino acid generated through the demethylation of methionine. It is largely catabolized by trans-sulfuration to cysteine, but it may also be remethylated to methionine. Regulation of homocysteine is dependent on nutrient intake, especially folate, vitamins B6 and B12.
L J, Langman, D E, Cole
openaire   +5 more sources

Homocysteine measurement by Vitros® Microtip homocysteine assay

Clinical Chemical Laboratory Medicine, 2008
Elevated circulating total homocysteine is an independent vascular risk factor. Enzymatic homocysteine measurements represent an alternative to HPLC- or immunochemistry-based assays, suitable for automation. Here, we report on analytical performance of a commercial cystathionine beta-synthase-based assay, for use on Vitros automated analyzers.Linear ...
Geert A, Martens, Joeri, De Nayer, Dieter, De Smet, Pedro, Couck, Frans, Gorus, Erik, Gerlo   +5 more
openaire   +2 more sources

Homocysteine and Gliotoxicity

Neurotoxicity Research, 2021
Homocysteine is a sulfur amino acid that does not occur in the diet, but it is an essential intermediate in normal mammalian metabolism of methionine. Hyperhomocysteinemia results from dietary intakes of Met, folate, and vitamin B12 and lifestyle or from the deficiency of specific enzymes, leading to tissue accumulation of this amino acid and/or its ...
Angela T. S. Wyse, Larissa Daniele Bobermin, Tiago Marcon dos Santos, André Quincozes-Santos   +3 more
openaire   +2 more sources