Results 241 to 250 of about 72,239 (257)
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Current Drug Metabolism, 2005
Plasma homocysteine concentration exhibits a strong relationship with (indices of) renal function. Hyperhomocysteinemia has been implicated in the high vascular event rate in patients with chronic renal failure. The precise pathophysiological explanation for the occurrence of hyperhomocysteinemia in renal failure is not yet elucidated.
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Plasma homocysteine concentration exhibits a strong relationship with (indices of) renal function. Hyperhomocysteinemia has been implicated in the high vascular event rate in patients with chronic renal failure. The precise pathophysiological explanation for the occurrence of hyperhomocysteinemia in renal failure is not yet elucidated.
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Clinical Chemistry and Laboratory Medicine, 2003
Indirect pathways, involving homocysteine (Hcy)-thiolactone and S-nitroso-Hcy, allow incorporation of Hcy into protein. Hcy-thiolactone, synthesized by methionyl-tRNA synthetase in all organisms investigated, including human, modifies proteins post-translationally by forming adducts in which Hcy is linked by amide bonds to epsilon-amino group of ...
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Indirect pathways, involving homocysteine (Hcy)-thiolactone and S-nitroso-Hcy, allow incorporation of Hcy into protein. Hcy-thiolactone, synthesized by methionyl-tRNA synthetase in all organisms investigated, including human, modifies proteins post-translationally by forming adducts in which Hcy is linked by amide bonds to epsilon-amino group of ...
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New England Journal of Medicine, 2002
Homocysteine is a simple amino acid that has recently received a great deal of attention as a risk factor for atherothrombotic vascular disease. There is reasonably compelling epidemiologic evidence of an association between the plasma homocysteine level and the risk of vascular disease in the coronary, carotid, and peripheral circulations.
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Homocysteine is a simple amino acid that has recently received a great deal of attention as a risk factor for atherothrombotic vascular disease. There is reasonably compelling epidemiologic evidence of an association between the plasma homocysteine level and the risk of vascular disease in the coronary, carotid, and peripheral circulations.
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Is Homocysteine Toxic in Uremia?
Journal of Renal Nutrition, 2008High levels of homocysteine have been implicated as a cardiovascular risk factor in the general population and in patients with chronic renal failure, and particularly patients on hemodialysis. To classify a risk factor as causally related to a certain disease, both strong epidemiologic data and sound basic-science studies establishing a mechanism are ...
PERNA, Alessandra +7 more
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2003
Homocysteine is an amino acid that is involved in several key metabolic processes, including the methylation and sulphuration pathways. Blood concentrations of homocysteine are determined by various dietary factors, including folic acid and vitamin B(12), by alteration in physiology, such as renal impairment, and by variation in the activity of enzymes
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Homocysteine is an amino acid that is involved in several key metabolic processes, including the methylation and sulphuration pathways. Blood concentrations of homocysteine are determined by various dietary factors, including folic acid and vitamin B(12), by alteration in physiology, such as renal impairment, and by variation in the activity of enzymes
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Is homocysteine a pro-oxidant?
Free Radical Research, 2001High plasma homocysteine concentrations have been found to be associated with atherosclerosis and thrombosis of arteries and deep veins. The oxidative damage mediated by hydrogen peroxide production during the metal-catalyzed oxidation of homocysteine is to date considered to be one of the major pathophysiological mechanisms for this association.
Giuseppe Ettore Martorana +7 more
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Homocysteine and blood pressure
Current Hypertension Reports, 2003Several studies, some population-based, have linked plasma homocysteine levels to blood pressure, especially systolic pressure. The strength of this association is weak, but may be underestimated due to inaccurate blood pressure measurements. In addition, the association may be confounded by renal function.
van Guldener, Coen +2 more
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Annual Review of Nutrition, 1999
▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or betaine in an alternative reaction); and transsulfuration to cystathionine, which requires pyridoxal-5′-phosphate.
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▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or betaine in an alternative reaction); and transsulfuration to cystathionine, which requires pyridoxal-5′-phosphate.
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Homocysteine and oxidative stress
Amino Acids, 2003Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put forward by several basic science ...
PERNA, Alessandra +2 more
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, 2001 Homocysteine was first described by Butz and du Vigneaud in 1932. They obtained the product by treating methionine with concentrated acid. This was the beginning of a most fascinating research story, which Finkelstein recently highlighted in a review (Finkelstein JD, 2000b).
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