Results 101 to 110 of about 1,456,033 (346)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Leibniz's Laws of Continuity and Homogeneity

, 2012
We explore Leibniz's understanding of the differential calculus, and argue that his methods were more coherent than is generally recognized. The foundations of the historical infinitesimal calculus of Newton and Leibniz have been a target of numerous ...
Katz, Mikhail G., Sherry, David
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The influence of the unloading mode of asphalt concrete mixing plant hot bin on the homogeneity of screened fractions [PDF]

Transport, 2004
The analysis of hot asphalt concrete mixture production in asphalt concrete mixing plants of intermittent operation according to the traditional technology scheme is presented.
H. Sivilevičius
doaj  

Symplectic Homogenization

Journal de l’École polytechnique — Mathématiques, 2022
Let H ( q , p ) be a Hamiltonian on
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Homogeneity in Social Groups of Iraq [PDF]

, 2006
Homogeneity in Social Groups of Iraqis Jon Gresham, Farouk Saleh, Shara Majid June 2006 With appreciation to the Royal Institute for Inter-Faith Studies for initiating the Second World Congress for Middle Eastern Studies, this paper summarizes findings
Gresham, Dr. Jon, Majid, Ms. Shara, Saleh, Mr. Farouk   +2 more
core  

Homogeneity of infinite dimensional isoparametric submanifolds

, 1998
A subset S of a Riemannian manifold N is called extrinsically homogeneous if S is an orbit of a subgroup of the isometry group of N. Thorbergsson proved the remarkable result that every complete, connected, full, irreducible isoparametric submanifold of ...
Heintze, Ernst, Liu, Xiaobo
core   +2 more sources

Electrical Mapping of Silver Nanowire Networks: A Versatile Tool for Imaging Network Homogeneity and Degradation Dynamics during Failure.

ACS Nano, 2018
Electrical stability and homogeneity of silver nanowire (AgNW) networks are critical assets for increasing their robustness and reliability when integrated as transparent electrodes in devices.
Thomas Sannicolo, N. Charvin, L. Flandin, Silas Kraus, Dorina T. Papanastasiou, C. Celle, J. Simonato, D. Muñoz‐Rojas, C. Jiménez, D. Bellet   +9 more
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source