Results 71 to 80 of about 80,156 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Analysis of effective properties of materials by using the boundary element method

open access: yesArchives of Mechanics, 2014
In this work different formulations of the boundary element method (BEM) in an analysis of materials with inclusions are presented. Models of composites in the form of linear-elastic solids containing rigid inclusions, elasto-plastic composites and ...
P. Fedeliński   +4 more
doaj   +1 more source

Fast and simple tool for the quantification of biofilm-embedded cells sub-populations from fluorescent microscopic images. [PDF]

open access: yesPLoS ONE, 2018
Fluorescent staining is a common tool for both quantitative and qualitative assessment of pro- and eukaryotic cells sub-population fractions by using microscopy and flow cytometry.
Mikhail I Bogachev   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Trace Element Distribution Patterns in Magnetically Separated Fractions of Fracture Filling Material

open access: yes, 1995
The distribution patterns of trace elements in magnetically separated fractions of a granite fracture filling material have been studied using instrumental neutron activation analysis.
D. Cui, T. E. Eriksen
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Alkylresorcinols of rye (Secale cereale L.) caryopses IV. Three-step preparation of 5-n-alkylresorcinols

open access: yesActa Societatis Botanicorum Poloniae, 2015
Whole rye or wheat grains were extracted with acetone at room temperature. The extracts were pooled and acetone was evaporated. The remaining acetone oil was washed out with n-pentane until a colourless filtrate was obtained.
W. Mejbaum-Katzenellenbogen   +2 more
doaj   +1 more source

Characteristics of molecular size fractions of humic substances derived from oxidized coal

open access: yes, 1992
Humic substances extracted from oxidized coal were fractionated by ultrafiltration in a MW sequence ranging from 500 to 50OK. Ultrafiltered fractions were analyzed by HPSEC and IR.
CELANO, Giuseppe   +4 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

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