Results 31 to 40 of about 117,721,879 (206)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Proceedings of Formal Methods in Computer Aided Design, FMCAD 2009 [PDF]
, 2009 Table of Contents: Preface (p. v) -- Organizing Committee (p. vii) -- Program Committee (p. vii) -- Referees (p. ix) -- Keynote Presentations (p. x) -- Tutorials (p. xii) -- Industrial Experience Reports (p. xiv) -- Panels (p. xvii) -- Session 1.
Formal Methods in Computer Aided Design
core +1 more source
Antea Group Archeologie 2020/137
, 2022 In juli en september 2020 heeft Antea Group in opdracht van BNVB Projects B.V. een archeologisch onderzoek uitgevoerd voor het plangebied ‘Grutterij 7-9’ te Amstelveen, gemeente Amstelveen.
Looveren, V. van (Antea Group)
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Baum-Connes conjecture for free orthogonal quantum groups [PDF]
, 2011 We prove an analogue of the Baum–Connes conjecture for free orthogonal quantum groups. More precisely, we show that these quantum groups have a γ-element and that γ=1. It follows that free orthogonal quantum groups are K-amenable.
Voigt, C. +2 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Homological topics in the representation theory of restricted Lie algebras [PDF]
, 1996 We present some recent developments in the application of homological methods to the representation theory of finite dimensional restricted Lie ...
Jörg Feldvoss, Feldvoss, Jorg
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