Results 331 to 340 of about 1,306,827 (384)

Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives. [PDF]

Reprod Biol Endocrinol
Wang X, Nie L, Hong Z, Li L, Fan Q, Ma B, Li Z, Gao Y, Zhang M, Zhang Y, Wang M.   +10 more
europepmc   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

A Practical CRISPR-Based Method for Rapid Genome Editing in <i>Caulobacter crescentus</i>. [PDF]

Bio Protoc
Yuan X, Yu X, Zhao W, Sun J.
europepmc   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

BAV-LLPS: a database of bacterial, archaea, and virus liquid-liquid phase separation proteins. [PDF]

Bioinformatics
Rodriguez CB, Tunque Cahui RR, Demitroff N, Hirsh L, Devos DP, Boccaccio G, Parisi G.   +6 more
europepmc   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Distinct humoral responses induced by heterologous versus homologous prime-boost immunization strategies in early life. [PDF]

Front Immunol
Foroutan Pajoohian P, Aradottir Pind AA, Molina Estupiñan JL, Christensen D, Pedersen GK, Olafsdottir TA, Jonsdottir I, Bjarnarson SP.   +7 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

The implications of alternative splicing regulation for maximum lifespan. [PDF]

Nat Commun
Jiang W, Zheng S, Chen L.
europepmc   +1 more source

Single-molecule sensing with an anthrax nanopore enabled by pH-asymmetric ionic liquids. [PDF]

J Nanobiotechnology
Zhang Z, Wang Y, Zhou S, Wang Y, Liu S, Guan X, Wang L.   +6 more
europepmc   +1 more source