Results 91 to 100 of about 1,161,690 (369)

Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping.

PLoS Genetics, 2020
In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by using a Chr VII disome system that can generate recombinants, chromosome loss, and ...
Rachel E Langston, Dominic Palazzola, Erin Bonnell, Raymund J Wellinger, Ted Weinert   +4 more
doaj   +1 more source

Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators.

PLoS Genetics, 2021
Reduction of genome ploidy from diploid to haploid necessitates stable pairing of homologous chromosomes into bivalents before the start of the first meiotic division.
Luisa Vernizzi, Christian F Lehner
doaj   +1 more source

DNA polymerase theta suppresses mitotic crossing over.

PLoS Genetics, 2021
Polymerase theta-mediated end joining (TMEJ) is a chromosome break repair pathway that is able to rescue the lethality associated with the loss of proteins involved in early steps in homologous recombination (e.g., BRCA1/2). This is due to the ability of
Juan Carvajal-Garcia, K Nicole Crown, Dale A Ramsden, Jeff Sekelsky   +3 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs [PDF]

, 2019
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are ...
Aguilera López, Andrés, Boulton, Simon J., Galindo Díaz, U., García Muse, Tatiana, García Rubio, María Luisa, Martin, Julie S., O'Reilly, N., Polanowska, Jolanta   +7 more
core   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source

Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Nature Communications, 2019
Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization ...
Adrián Gonzalo, Marie-Odile Lucas, Catherine Charpentier, Greta Sandmann, Andrew Lloyd, Eric Jenczewski   +5 more
doaj   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Bio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis, Sha Cao, Diarmaid Hughes   +2 more
doaj   +1 more source

CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. [PDF]

PLoS Genetics, 2008
The synaptonemal complex (SC), a tripartite proteinaceous structure that forms between homologous chromosomes during meiosis, is crucial for faithful chromosome segregation.
Sarit Smolikov, Kristina Schild-Prüfert, Mónica P Colaiácovo   +2 more
doaj   +1 more source