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Homologous Association of Oppositely Imprinted Chromosomal Domains

Science, 1996
Human chromosome 15q11-q13 encompasses the Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) loci, which are subject to parental imprinting, a process that marks the parental origin of certain chromosomal subregions. A temporal and spatial association between maternal and paternal chromosomes 15 was observed in human T lymphocytes by three ...
Janine M. LaSalle, Marc Lalande
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2 Is X-chromosome inactivation a homology effect?

2002
Homology effect is defined as any effect on gene expression or chromosome behavior relating to the presence of homologous sequences. Using this definition, imprinted X inactivation probably does not qualify as a homology effect, since paternal silencing is strictly the result of gametic imprinting and occurs without regard to total X-chromosome number.
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A study of homologous chromosomes using a morphometric approach

Genome, 1993
A previous study of 100 karyotyped metaphase cells has demonstrated the utility of a graphic arts tool in deriving chromosome measurements for relative length determination. In the present study we utilize this same approach to address the question: "What are the average differences in relative lengths between apparently normal homologous chromosomes?"
Roger Mark   +6 more
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Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.

Genomics, 1996
The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes.
J. Tischfield   +11 more
semanticscholar   +1 more source

Homologous Recombination Using Bacterial Artificial Chromosomes

Cold Spring Harbor Protocols, 2015
This protocol introduces the technique of homologous recombination in bacteria to insert a linear DNA fragment into bacterial artificial chromosomes (BACs). Homologous recombination allows the modification of large DNA molecules, in contrast with conventional restriction endonuclease-based strategies, which cleave large DNAs into numerous fragments and
Elizabeth Munroe   +3 more
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Homologous chromosome pairing: The physical problem

Journal of Genetics, 1942
Homologous pairing of chromosomes is discussed in its physical aspects. The relevant facts about the cytology of pairing are examined, and the conditions stated which must be satisfied by any physical explanation. It is pointed out that these requirements are at first sight contradictory.
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Phase separation drives pairing of homologous chromosomes

Current Genetics, 2020
Pairing of homologous chromosomes is crucial for ensuring accurate segregation of chromosomes during meiosis. Molecular mechanisms of homologous chromosome pairing in meiosis have been extensively studied in the fission yeast Schizosaccharomyces pombe.
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Homologous pairing and chromosome dynamics in meiosis and mitosis

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2004
Pairing of homologous chromosomes is an essential feature of meiosis, acting to promote high levels of recombination and to ensure segregation of homologs. However, homologous pairing also occurs in somatic cells, most regularly in Dipterans such as Drosophila, but also to a lesser extent in other organisms, and it is not known how mitotic and meiotic ...
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