Results 71 to 80 of about 181,925 (222)

Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. [PDF]

Sci Adv, 2022
Roy S, Juste SS, Sneider M, Auradkar A, Klanseck C, Li Z, Julio AHF, Lopez del Amo V, Bier E, Guichard A.   +9 more
europepmc   +1 more source

Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer

Advanced Science, EarlyView.
KLF5 is highly expressed in BLBC patients and promotes Cyclin D1 and XPO1 transcription, ultimately leading to the inactivation of RB1. Both XPO1 inhibitor (KPT‐330) and CDK4/6 inhibitor (Palbociclib) can enhance RB1 activity and exert antitumor effects. It has been proved that the combination of KPT‐330 and Palbociclib can inhibit the proliferation of
Yu Tang, Rui Liu, Jing Zhu, Qian He, Chenglong Pan, Zhongmei Zhou, Jian Sun, Fubing Li, Longlong Zhang, Yujie Shi, Jing Yao, Dewei Jiang, Ceshi Chen   +12 more
wiley   +1 more source

Homologous chromosome associations in domains before meiosis could facilitate chromosome recognition and pairing in wheat. [PDF]

Sci Rep, 2022
Barea L, Redondo-Río Á, Lucena-Marín R, Serrano-Heredia S, Aguilar M, Prieto P.   +5 more
europepmc   +1 more source

hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A‐Dependent Manner and is Essential for Meiosis

Advanced Science, EarlyView.
This work shows that hnRNPC recognizes and binds directly to key meiosis‐related genes and works with HuR to regulate alternative splicing of its target genes, ensuring the normal production and proper function of essential meiotic transcripts required for meiotic initiation and progression during the first wave of spermatogenesis.
Xinxin Xiong, Shenglei Feng, Xixiang Ma, Kuan Liu, Yiqian Gui, Bei Chen, Xu Fan, Fengli Wang, Xiaoli Wang, Shuiqiao Yuan   +9 more
wiley   +1 more source

Decay of homologous chromosome pairs and discovery of males in the thelytokous fungus-growing ant Mycocepurus smithii. [PDF]

Sci Rep, 2022
Barros LAC, Rabeling C, Teixeira GA, Dos Santos Ferreira Mariano C, Delabie JHC, de Aguiar HJAC.   +5 more
europepmc   +1 more source

Genome‐Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat

Advanced Science, EarlyView.
In this study, variation and genetic basis of ionome among Tartary buckwheat population are investigated, illuminating their significance in the domestication and diversification of Tartary buckwheat. And three genes (FtACA13 for Na content, FtYPQ1 for Zn content, FtNHX2 for As content) are identified with the dominant haplotypes and functional ...
Zhirong Wang, Yuqi He, Mengyu Zhao, Xiang‐Qian Liu, Hao Lin, Yaliang Shi, Kaixuan Zhang, Guijie Lei, Dili Lai, Tong Liu, Xiaoyang Peng, Jiayue He, Wei Li, Xiangru Wang, Sun‐Hee Woo, Muriel Quinet, Alisdair R. Fernie, Xin‐Yuan Huang, Meiliang Zhou   +18 more
wiley   +1 more source

The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis. [PDF]

Cell Rep, 2021
Cheng EC, Hsieh CL, Liu N, Wang J, Zhong M, Chen T, Li E, Lin H.   +7 more
europepmc   +1 more source

Discovery of Phylogenetic Relevant Y-chromosome Variants in 1000 Genomes Project Data [PDF]

arXiv, 2013
Current Y chromosome research is limited in the poor resolution of Y chromosome phylogenetic tree. Entirely sequenced Y chromosomes in numerous human individuals have only recently become available by the advent of next-generation sequencing technology. The 1000 Genomes Project has sequenced Y chromosomes from more than 1000 males.
arxiv  

Metabolic Engineering of Corynebacterium glutamicum for High‐Level Production of 1,5‐Pentanediol, a C5 Diol Platform Chemical

Advanced Science, EarlyView.
This study develops an efficient biosynthesis system for 1,5‐pentanediol (1,5‐PDO) in Corynebacterium glutamicum, an important compound for industrial applications. By engineering the l‐lysine degradation pathway, 5‐hydroxyvaleric acid (5‐HV) is synthesized from glucose as a key intermediate.
Yu Jung Sohn, Se‐Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin‐Byung Park, Si Jae Park   +11 more
wiley   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source