Results 181 to 190 of about 147,193 (248)

The role of mitochondrial fusion protein 2 in regulating ER stress in premature placental aging: A case-control study. [PDF]

Medicine (Baltimore)
Sun D, Ai L, Xu P, Zhou J, Xue L.
europepmc   +1 more source

A single base‐pair variation in a limb‐specific Lhx9 cis‐regulatory region modulates HAND2‐associated posterior repression

Developmental Dynamics, EarlyView.
Abstract LIM Homeobox 9 (Lhx9) is a transcription factor involved in vertebrate limb development. Despite conserved anterior expression, its distal expression is species‐specific. In chickens, distal expression is restricted to the anterior mesoderm; in mice, it extends into posterior mesoderm.
Jeanyoung Kim, Grace Santrach, William M. Sparks, Molly Ahola, Jessica C. Britton, Novalee Erickson, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg   +9 more
wiley   +1 more source

EXPRESSION OF CONCERN: Overexpression of TNKS1BP1 in Lung Cancers and Its Involvement in Homologous Recombination Pathway of DNA Double-Strand Breaks. [PDF]

Cancer Med
europepmc   +1 more source

A fish-specific E3 ubiquitin ligase NHRE3 suppresses antiviral immunity by degrading ISG15 via ubiquitination. [PDF]

PLoS Pathog
Xie J, Lei J, Zhu Q, Gui B, Li Y, Wang Y, Huang R.   +6 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The Key <i>Trichoderma</i>-Induced Gene Encoding a DUF568 Domain-Containing Protein Mediates Defense Responses in Wheat. [PDF]

Plants (Basel)
Li J, Jin Y, Wang Y, Wang T, Zhang H, Ni Y.   +5 more
europepmc   +1 more source

Human induced pluripotent stem cell‐derived cortical neurons from monozygotic twins with the Gαo1K278del mutation reveal disease mechanisms relevant to GNAO1‐related encephalopathy

Epilepsia, EarlyView.
Abstract Objective Rare de novo variants in GNAO1 cause a severe neurodevelopmental disorder characterized by a heterogenous display of early onset epilepsy, movement abnormalities, and global developmental delay. More than 100 pathogenic variants in GNAO1 have been identified and categorized into four groups according to their protein features.
Maria Sáez González, Kes Kloosterhuis, Jeroen Vreijling, Hailiang Mei, Tom P. Hellings, Davide Pirolli, Anine H. Stam, Arn M. J. M. van den Maagdenberg, Vivi M. Heine, Jean‐Philippe Frimat, Laura A. van de Pol, Frank Baas, Harald M. M. Mikkers   +12 more
wiley   +1 more source

An advanced genome engineering platform for Komagataella phaffii enabling versatile in vivo DNA assembly and multiplex integration. [PDF]

J Biol Eng
Choi Y, Kim A, Kang NK.
europepmc   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer. [PDF]

Cell Death Dis
Yu Y, Wu H, Xiao Y, Qiu J, Hong L, Yang B, Wang J, Wang Z, Shao L, Xu B, Wu J.   +10 more
europepmc   +1 more source