Results 1 to 10 of about 1,435,507 (315)

Frataxin overexpressing mice

FEBS Letters, 2004
Friedreich ataxia, the most common autosomal recessive ataxia, is caused by frataxin deficiency. Reduction of frataxin has been associated with iron accumulation and sensitivity to iron induced oxidative stress. To better understand the function of frataxin, transgenic mice (tgFxn) overexpressing human frataxin were generated.
Miranda, C, Santos, M M, Ohshima, K, Tessaro, Marco, Sequeiros, Jorge, Pandolfo, Massimo   +5 more
openaire   +3 more sources

Endocan Overexpression in Pterygium

Cornea, 2017
Purpose: The aim of this study was to evaluate the possible role of endocan in the pathogenesis of pterygium. Methods: The study was conducted on 33 patients with primary pterygium and 20 control subjects with normal bulbar conjunctiva.
Kilic, Rasit, Kurt, Ali, Tad, Murat, Tasdemir, Sedat   +3 more
openaire   +2 more sources

Perspectives on blockade of TGFβ overexpression [PDF]

Kidney International, 2006
Many approaches to blocking profibrotic TGFbeta overexpression are under way. Therapeutic targeting of TGFbeta-Smad signaling holds promise for slowing or halting progressive renal disease. In this issue, Fukasawa et al., using the unilateral ureteral obstruction model, provide a new target for therapeutic intervention by identifying loss of the Smad ...
Huang, Y., Border, W.A., Noble, N.A.
openaire   +2 more sources

Galanin overexpressing transgenic mice [PDF]

Neuropeptides, 2002
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT).
Bartfai, Tamas, Hohmann, John G., Steiner, Robert A., Xu, Zhi-Qing D., Xu, Xiao-Jun, Holmberg, Kristina, Blakeman, Karin H., Hokfelt, Tomas, Mufson, Elliott J., Crawley, Jacqueline N., Wiesenfeld-Hallin, Zsuzsanna, Teklemichael, Dawit N.   +11 more
openaire   +2 more sources

Securin is overexpressed in breast cancer [PDF]

Modern Pathology, 2005
Securin regulates sister chromatid separation during mitosis, induces bFGF-mediated angiogenesis, and securin overexpression causes in vitro transformation and in vivo tumor formation in nude mice. As estrogen administration to oophorectomized rats increased pituitary securin expression, we used immunohistochemistry to examine securin and estrogen ...
Selam, Ogbagabriel, Manory, Fernando, Frederic M, Waldman, Shikha, Bose, Anthony P, Heaney   +4 more
openaire   +2 more sources

NUCKS overexpression in breast cancer [PDF]

Cancer Cell International, 2009
Abstract Background NUCKS (Nuclear, Casein Kinase and Cyclin-dependent Kinase Substrate) is a nuclear, DNA-binding and highly phosphorylated protein. A number of reports show that NUCKS is highly expressed on the level of mRNA in several human cancers, including breast cancer.
Drosos, Yiannis, Kouloukoussa, Mirsini, Østvold, Anne C, Grundt, Kirsten, Goutas, Nikos, Vlachodimitropoulos, Dimitrios, Havaki, Sophia, Kollia, Panagoula, Kittas, Christos, Marinos, Evangelos, Aleporou-Marinou, Vassiliki   +10 more
openaire   +6 more sources

MicroRNA and HER2-overexpressing Cancer [PDF]

MicroRNA, 2013
The discovery of microRNAs (miRNAs) has opened up new avenues for studying cancer at the molecular level, featuring a post-genomic era of biomedical research. These non-coding regulatory RNA molecules of ~22 nucleotides have emerged as important cancer biomarkers, effectors, and targets.
Wang, Shizhen Emily, Lin, Ren-Jang
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A neuroglobin-overexpressing transgenic mouse [PDF]

Gene, 2007
Neuroglobin (Ngb) is a recently discovered vertebrate globin expressed primarily in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons from these insults. However, its normal physiological role and the mechanism underlying its neuroprotective action are uncertain. We report production of a transgenic mouse in which Ngb
Adil A, Khan, Yunjuan, Sun, Kunlin, Jin, Xiao Ou, Mao, Sylvia, Chen, Lisa M, Ellerby, David A, Greenberg   +6 more
openaire   +2 more sources