Results 11 to 20 of about 1,171,772 (218)

Pattern of HER2 Overexpression in Urinary Bladder Carcinomas in Kano, Nigeria

The Annals of African Surgery, 2023
Background: The worldwide distribution of bladder cancer varies, conforming to differences in environmental and genetic risk factors. HER2 neu is overexpressed in many human cancers, including urinary bladder carcinomas.
Muhammad Sanusi Haruna, Akinfenwa Taoheed Atanda, Yawale Iliyasu   +2 more
doaj   +2 more sources

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source

The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity [PDF]

, 2014
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects.
Chilumuri, A.
core   +1 more source

RsSOS1 Responding to Salt Stress Might Be Involved in Regulating Salt Tolerance by Maintaining Na⁺ Homeostasis in Radish (Raphanus sativus L.)

Horticulturae, 2021
Radish is a kind of moderately salt-sensitive vegetable. Salt stress seriously decreases the yield and quality of radish. The plasma membrane Na+/H+ antiporter protein Salt Overly Sensitive 1 (SOS1) plays a crucial role in protecting plant cells against ...
Wanting Zhang, Jingxue Li, Junhui Dong, Yan Wang, Liang Xu, Kexin Li, Xiaofang Yi, Yuelin Zhu, Liwang Liu   +8 more
doaj   +1 more source

Frataxin overexpressing mice

FEBS Letters, 2004
Friedreich ataxia, the most common autosomal recessive ataxia, is caused by frataxin deficiency. Reduction of frataxin has been associated with iron accumulation and sensitivity to iron induced oxidative stress. To better understand the function of frataxin, transgenic mice (tgFxn) overexpressing human frataxin were generated.
Miranda, C, Santos, M M, Ohshima, K, Tessaro, Marco, Sequeiros, Jorge, Pandolfo, Massimo   +5 more
openaire   +3 more sources

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Paul S Sharp, Dominic J. Wells, Ke Liu, Susan C Brown, Sharp, P S, Dominic J Wells, Cirak, S., Sebahattin Cirak, Wells, DJ, Paul S. Sharp, Muntoni, F., Susan C. Brown, Wells, D J, Brockington, M., Cirak, S, Liu, K., Brockington, M, Torelli, S, Brown, SC, Sharp, PS, Muntoni, F, Brown, S C, Sharp, P.S., Torelli, S., Liu, K, Wells, D.J., Silvia Torelli, Brockington, M A, Francesco Muntoni, Martin Brockington, Brown, S.C.   +30 more
core   +1 more source

The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones

Molecules, 2022
Salvia miltiorrhiza is a medicinal plant that synthesises biologically-active tanshinones with numerous therapeutic properties. An important rate-limiting enzyme in the biosynthesis of their precursors is 3-hydroxy-3-methylglutaryl-coenzyme A reductase ...
Małgorzata Majewska, Piotr Szymczyk, Jan Gomulski, Agnieszka Jeleń, Renata Grąbkowska, Ewa Balcerczak, Łukasz Kuźma   +6 more
doaj   +1 more source

Improvement of Nemadectin Production by Overexpressing the Regulatory Gene nemR and Nemadectin Biosynthetic Gene Cluster in Streptomyces Cyaneogriseus

Pharmaceutical Fronts, 2020
Nemadectin, a 16-member macrocyclic lactone antiparasitic antibiotic, is produced by Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin, a C-23 oximate derivative of nemadectin, is widely used as a pesticide due to its broad-spectrum, highly
Yuan-Jie Wu, Song-Bai Yang, Zheng-Yu Zhang, Shao-Xin Chen   +3 more
doaj   +1 more source

AgMYB1, an R2R3-MYB factor, plays a role in anthocyanin production and enhancement of antioxidant capacity in celery

Vegetable Research, 2021
Celery is rich in nutrients and cultivated worldwide. Anthocyanins are natural plant pigments with high antioxidant capabilities in the human diet. The accumulation of anthocyanins in celery results in the purple skin color of petioles. Here, an R2R3-MYB
Kai Feng, Guo-Ming Xing, Jie-Xia Liu, Hao Wang, Guo-Fei Tan, Guang-Long Wang, Zhi-Sheng Xu, Ai-Sheng Xiong   +7 more
doaj   +1 more source

FFGA1 Protein Is Essential for Regulating Vegetative Growth, Cell Wall Integrity, and Protection against Stress in Flammunina filiformis

Journal of Fungi, 2022
Flammulina filiformis is a popular mushroom which has been regarded as a potential model fungus for mycelium growth, fruiting body development, and stress response studies.
Muyun Du, Yongbo Xie, Meng Wang, Huan Yang, Banghui Hu, Irum Mukhtar, Yuanyuan Liu, Yongxin Tao, Fang Liu, Baogui Xie   +9 more
doaj   +1 more source