Results 11 to 20 of about 1,435,507 (315)

Quantitative nature of overexpression experiments

Molecular Biology of the Cell, 2015
Overexpression experiments are sometimes considered as qualitative experiments designed to identify novel proteins and study their function. However, in order to draw conclusions regarding protein overexpression through association analyses using large-scale biological data sets, we need to recognize the quantitative nature of overexpression ...
H. Moriya
openaire   +3 more sources

Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis

BMC Cancer, 2021
Breast cancer (BC) is a leading cause of cancer-related death in females worldwide. Previous studies have demonstrated that matrix metalloproteinases (MMPs) play key roles in metastasis and are associated with survival in various cancers.
Hanfang Jiang, Huiping Li
semanticscholar   +1 more source

SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

Molecular Therapy: Nucleic Acids, 2020
Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury, coronary circulation is a so far neglected target of cardioprotection. In this study, we investigated the molecular mechanisms underlying I/R injury to cardiac
Ying Tan, D. Mui, Sam Toan, Pingjun Zhu, Ruibing Li, Hao Zhou   +5 more
semanticscholar   +1 more source

Pattern of HER2 Overexpression in Urinary Bladder Carcinomas in Kano, Nigeria

, 2023
Background: The worldwide distribution of bladder cancer varies, conforming to differences in environmental and genetic risk factors. HER2 neu is overexpressed in many human cancers, including urinary bladder carcinomas.
Yawale Iliyasu, Muhammad Sanusi Haruna, Akinfenwa Taoheed Atanda   +2 more
core   +1 more source

c-Jun overexpression in CAR T cells induces exhaustion resistance

Nature, 2019
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1–3, but dysfunction due to T cell exhaustion is an important barrier to progress4–6.
Rachel C. Lynn, Evan W. Weber, E. Sotillo, D. Gennert, P. Xu, Zinaida Good, H. Anbunathan, John Lattin, Robert B Jones, Victor Tieu, S. Nagaraja, Jeffrey M. Granja, Charles DeBourcy, R. Majzner, Ansuman T. Satpathy, S. Quake, Michelle Monje, Howard Y. Chang, C. Mackall   +18 more
semanticscholar   +1 more source

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl

Journal of Experimental Medicine, 1995
A critical event during programmed cell death (PCD) appears to be the acquisition of plasma membrane (PM) changes that allows phagocytes to recognize and engulf these cells before they rupture.
S. Martin, Chris P. M. Reutelingsperger, A. Mcgahon, James A. Rader, R. V. van Schie, D. Laface, D. Green   +6 more
semanticscholar   +1 more source

The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity [PDF]

, 2014
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects.
Chilumuri, A.
core   +1 more source

Overexpression of SrDXS1 and SrKAH enhances steviol glycosides content in transgenic Stevia plants

BMC Plant Biology, 2019
Stevia rebaudiana produces sweet-tasting steviol glycosides (SGs) in its leaves which can be used as natural sweeteners. Metabolic engineering of Stevia would offer an alternative approach to conventional breeding for enhanced production of SGs. However,
Junshi Zheng, Zhuang Yan, H. Mao, I. Jang   +3 more
semanticscholar   +1 more source

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Paul S Sharp, Dominic J. Wells, Ke Liu, Susan C Brown, Sharp, P S, Dominic J Wells, Cirak, S., Sebahattin Cirak, Wells, DJ, Paul S. Sharp, Muntoni, F., Susan C. Brown, Wells, D J, Brockington, M., Cirak, S, Liu, K., Brockington, M, Torelli, S, Brown, SC, Sharp, PS, Muntoni, F, Brown, S C, Sharp, P.S., Torelli, S., Liu, K, Wells, D.J., Silvia Torelli, Brockington, M A, Francesco Muntoni, Martin Brockington, Brown, S.C.   +30 more
core   +1 more source