Results 21 to 30 of about 1,435,507 (315)
Skeletal-Muscle-Specific Overexpression of Chrono Leads to Disruption of Glucose Metabolism and Exercise Capacity [PDF]
, 2022 Disruption of circadian rhythms is related to disorders of glucose metabolism, and the molecular clock also exists in skeletal muscle. The ChIP-derived repressor of network oscillator (Chrono) and brain and muscle ARNT-like 1 (Bmal1) are core circadian ...
Wei, Hao +13 more
core +1 more source
The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors
Cancer Cell International, 2019 The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 ubiquitin ligase, and the ubiquitinated p53 can be transferred to the cytoplasm and
H. Hou, Dantong Sun, Xiaochun Zhang
semanticscholar +1 more source
Molecular Biology International, 2014 Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in the autophosphorylation of tyrosine residues within the cytoplasmic domain
N. Iqbal, N. Iqbal
semanticscholar +1 more source
Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
Nature Communications, 2019 The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tauP301L expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrain ...
Julia E. Gamache +7 more
semanticscholar +1 more source
, 2020 Glioblastoma multiforme (GBM) is the most common and malignant type of central nervous system tumours in adults. Strict regulation of glucose homeostasis has a significant role in GBM pathogenesis.
Gorgisen, Gökhan +3 more
core +1 more source
Nature Communications, 2018 Drought represents a major threat to food security. Mechanistic data describing plant responses to drought have been studied extensively and genes conferring drought resistance have been introduced into crop plants.
Norma Fàbregas +14 more
semanticscholar +1 more source
Overexpression of the Cytokine BAFF and Autoimmunity Risk
New England Journal of Medicine, 2017 BACKGROUND Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions in the genome. However, only for a few association signals has the causal gene been identified, and for even fewer have the causal variant and
M. Steri +80 more
semanticscholar +1 more source
Overexpression of OsNAC14 Improves Drought Tolerance in Rice
Frontiers in Plant Science, 2018 Plants have evolved to have sophisticated adaptation mechanisms to cope with drought stress by reprograming transcriptional networks through drought responsive transcription factors.
J. Shim +5 more
semanticscholar +1 more source
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]
, 2012 Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K. +41 more
core +1 more source
Cell, 2009 SUMMARY The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR, also called DEPDC6, as an mTOR-interacting protein whose expression is negatively regulated by mTORC1 and mTORC2. Loss of DEPTOR activates S6K1,
Timothy R. Peterson +7 more
semanticscholar +1 more source