Results 21 to 30 of about 1,203,145 (219)

Expression of the Fluoroquinolones Efflux Pump Genes acrA and mdfA in Urinary Escherichia coli Isolates [PDF]

open access: yesPolish Journal of Microbiology, 2017
Escherichia coli is one of the most frequent causes of urinary tract infections. Efflux system overexpression is reported to contribute to E. coli resistance to several antibiotics. Our aim in this study was to investigate the relation between antibiotic
Sarah M. Abdelhamid, Rania R. Abozahra
doaj   +1 more source

Depleting Tumor Cells Expressing Immune Checkpoint Ligands—A New Approach to Combat Cancer

open access: yesCells, 2021
Antibodies against inhibitory immune checkpoint molecules (ICPMs), referred to as immune checkpoint inhibitors (ICIs), have gained a prominent place in cancer therapy.
Fabrizio Marcucci, Cristiano Rumio
doaj   +1 more source

c-erbB-2 expression in benign and malignant breast disease. [PDF]

open access: yes, 1988
An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA   +17 more
core   +1 more source

The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity [PDF]

open access: yes, 2014
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects.
Chilumuri, A.
core   +1 more source

RsSOS1 Responding to Salt Stress Might Be Involved in Regulating Salt Tolerance by Maintaining Na+ Homeostasis in Radish (Raphanus sativus L.)

open access: yesHorticulturae, 2021
Radish is a kind of moderately salt-sensitive vegetable. Salt stress seriously decreases the yield and quality of radish. The plasma membrane Na+/H+ antiporter protein Salt Overly Sensitive 1 (SOS1) plays a crucial role in protecting plant cells against ...
Wanting Zhang   +8 more
doaj   +1 more source

Frataxin overexpressing mice

open access: yesFEBS Letters, 2004
Friedreich ataxia, the most common autosomal recessive ataxia, is caused by frataxin deficiency. Reduction of frataxin has been associated with iron accumulation and sensitivity to iron induced oxidative stress. To better understand the function of frataxin, transgenic mice (tgFxn) overexpressing human frataxin were generated.
Miranda, C   +5 more
openaire   +3 more sources

The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones

open access: yesMolecules, 2022
Salvia miltiorrhiza is a medicinal plant that synthesises biologically-active tanshinones with numerous therapeutic properties. An important rate-limiting enzyme in the biosynthesis of their precursors is 3-hydroxy-3-methylglutaryl-coenzyme A reductase ...
Małgorzata Majewska   +6 more
doaj   +1 more source

Improvement of Nemadectin Production by Overexpressing the Regulatory Gene nemR and Nemadectin Biosynthetic Gene Cluster in Streptomyces Cyaneogriseus

open access: yesPharmaceutical Fronts, 2020
Nemadectin, a 16-member macrocyclic lactone antiparasitic antibiotic, is produced by Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin, a C-23 oximate derivative of nemadectin, is widely used as a pesticide due to its broad-spectrum, highly
Yuan-Jie Wu   +3 more
doaj   +1 more source

AgMYB1, an R2R3-MYB factor, plays a role in anthocyanin production and enhancement of antioxidant capacity in celery

open access: yesVegetable Research, 2021
Celery is rich in nutrients and cultivated worldwide. Anthocyanins are natural plant pigments with high antioxidant capabilities in the human diet. The accumulation of anthocyanins in celery results in the purple skin color of petioles. Here, an R2R3-MYB
Kai Feng   +7 more
doaj   +1 more source

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

open access: yes, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K.   +41 more
core   +2 more sources

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