Results 41 to 50 of about 1,435,507 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis

, 2016
Cell cycle genes are often aberrantly expressed in cancer, but how their misexpression drives tumorigenesis mostly remains unclear. From S phase to early mitosis, EMI1 (also known as FBXO5) inhibits the anaphase-promoting complex/cyclosome, which ...
Cato, K, Pavey, S., Gabrielli, BG, Duijf, PHG, Vaidyanathan, S, Tang, L., Haass, NK, Vaidyanathan, S., Duijf, P.H.G., Pavey, S, Haass, N.K., Gabrielli, B.G., Tang, L, Cato, K.   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Science, 2008
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells.
S. Varambally, Q. Cao, R. Mani, Sunita Shankar, Xiaosong Wang, Bushra Ateeq, B. Laxman, Xuhong Cao, Xiaojun Jing, Kalpana Ramnarayanan, J. Brenner, Jindan Yu, J. H. Kim, B. Han, P. Tan, Chandan Kumar-Sinha, R. Lonigro, N. Palanisamy, C. Maher, A. Chinnaiyan   +19 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer

OncoTarget, 2014
Long non-coding RNAs (lncRNAs) play key roles in the progression and metastasis of some carcinomas. We previously showed that the expression of lncRNA H19 (H19) was higher in gastric cancer (GC) tissues than that in paired noncanerous tissues.
Hao Li, Beiqin Yu, Jianfang Li, Liping Su, M. Yan, Zhenggang Zhu, Bing-ya Liu   +6 more
semanticscholar   +1 more source

c-erbB-2 expression in benign and malignant breast disease.

, 1988
An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA, NM Gibbs, S Harrison, BA Gusterson, Powles, TJ, C Elliott, TJ Powles, Monaghan, P, S Ashley, Ashley, S, LG Machin, Gullick, WJ, Gibbs, NM, P Monaghan, Machin, LG, Elliott, C, Harrison, S, WJ Gullick   +17 more
core   +1 more source

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

, 2023
BACKGROUND: αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers.
Apaja, Pirjo M., Sharma, Sowmya, Bain, Amanda Louise, Behnam Rashidieh, Duijf, Pascal H.G., John Finnie, Stewart, Cameron Allan, Pascal H. G. Duijf, Pirjo M. Apaja, Sowmya Sharma, Khanna, Kum Kum, Duijf, Pascal H. G., Simon Manuel Tria, Cameron Allan Stewart, Jacinta Ley Simmons, Apaja, Pirjo M, Duijf, Pascal HG, Simmons, Jacinta Ley, Rashidieh, Behnam, Finnie, John, Kum Kum Khanna, Amanda Louise Bain, https://orcid.org/, Tria, Simon Manuel   +23 more
core   +1 more source

Propagation Failure by TRPM4 Overexpression [PDF]

Biophysical Journal, 2019
Transient receptor potential melastatin member 4 (TRPM4) channels are nonselective monovalent cationic channels found in human atria and conduction system. Overexpression of TRPM4 channels has been found in families suffering from inherited cardiac arrhythmias, notably heart block.
Gaur, Namit, Hof, Thomas, Haïssaguerre, Michel, Vigmond, Edward   +3 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source