Results 51 to 60 of about 1,435,507 (315)

Fibroblast Activation Protein Overexpression and Clinical Implications in Solid Tumors: A Meta-Analysis

PLoS ONE, 2015
Objective Fibroblast activation protein (FAP) plays a vital role in tumor invasion and metastasis. Previous studies have reported its prognostic value in different tumors. However, the results of these reports remain controversial.
Fang Liu, L. Qi, Baogang Liu, Jie Liu, Hua Zhang, Dehai Che, Jingyan Cao, Jing Shen, Jianxiong Geng, Y. Bi, L. Ye, B. Pan, Yan Yu   +12 more
semanticscholar   +1 more source

Overexpression of ca1pase decreases Rubisco abundance and grain yield in wheat [PDF]

, 2019
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the fixation of CO2 into organic compounds that are used for plant growth and production of agricultural products.
Parry, J., Orr, D., Lobo, A. K. M., Andralojc, P. J., Parry, M. A. J., Afan, M., Gutierrez, M. O., Sparks, C. A., Carmo-Silva, E.   +8 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Nature Communications, 2013
Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of
Jong-Ok Pyo, Seung-Min Yoo, Hye-Hyun Ahn, Jihoon Nah, Se-hoon Hong, T. Kam, Sunmin Jung, Yong-Keun Jung   +7 more
semanticscholar   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Phospholamban overexpression in transgenic rabbits [PDF]

Transgenic Research, 2007
There has been considerable interest in pursuing phospholamban as a putative therapeutic target for overcoming depressed calcium handling in human heart failure. Studies predominantly done in mice have shown that phospholamban is a key regulator of sarcoplasmic reticulum calcium cycling and cardiac function.
James Scott, Pattison, Jason R, Waggoner, Jeanne, James, Lisa, Martin, James, Gulick, Hanna, Osinska, Raisa, Klevitsky, Evangelia G, Kranias, Jeffrey, Robbins   +8 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Cep55 overexpression promotes genomic instability and tumorigenesis in mice [PDF]

, 2020
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal ...
Khanna, KK, Finnie, John. W., Nanayakkara, D, Bain, Amanda L, Burgess, Andrew, Duijf, PHG, Smits, VAJ, Nanayakkara, Devathri, Nag, P, Wall, M, Raninga, Prahlad, Kalimutho, Murugan, Burgess, A., Wall, M., Smits, Veronique AJ, Finnie, J.W., Wall, Meaghan, Burgess, A, Duijf, Pascal H. G., Sinha, D., Smits, Veronique A. J., Nanayakkara, D., Duijf, Pascal HG, Bain, Amanda L., Kalimutho, M., Kalimutho, M, Sinha, Debottam, Raninga, P., Finnie, JW, Nag, P., Subramanian, Goutham, Raninga, P, Subramanian, G., Khanna, Kum Kum, Duijf, P.H.G., Sinha, D, Nag, Purba, Subramanian, G, Smits, V.A.J., Bain, AL, Bain, A.L., Khanna, K.K., Finnie, John W   +42 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source