Results 71 to 80 of about 1,507,610 (341)

Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation

, 2015
Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential
Furusawa, Chikara, Kaneko, Kunihiko, Miyamoto, Tadashi   +2 more
core   +3 more sources

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-wide identification and characterization of 14-3-3 gene family related to negative regulation of starch accumulation in storage root of Manihot esculenta

Frontiers in Plant Science, 2023
The 14-3-3 protein family is a highly conservative member of the acid protein family and plays an important role in regulating a series of important biological activities and various signal transduction pathways. The role of 14-3-3 proteins in regulating
Ranran Pan, Ranran Pan, Yajie Wang, Feifei An, Yuan Yao, Jingjing Xue, Wenli Zhu, Xiuqin Luo, Hanggui Lai, Songbi Chen   +9 more
doaj   +1 more source

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway [PDF]

, 2015
Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens.
Drakaki, A, Georgoulias, V, Hatziapostolou, M, Iliopoulos, D, Polytarchou, C, Poultsides, GA, Souglakos, J, Vorvis, C   +7 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells. [PDF]

, 2015
Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in high-risk preneoplastic lesions and in primary breast tumors where it correlates with HER2 ...
Circo, R, De Maria, R, Di Benedetto, A, Di Modugno, F, Matteoni, S, Melchionna, R, Mottolese, M, Nisticò, P. 1., Palermo, Belinda, Soddu, S, Spada, Sheila, Trono, P   +11 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM

Вавиловский журнал генетики и селекции, 2015
Overexpression of the Gadd45 gene in the nervous system of Drosophila melanogaster increases the life span. We have performed the Gompertz approximation of the survival curve and revealed a life span increase as a result of decrease of the R parameter ...
E. N. Plyusnina, M. V. Shaposhnikov, E. N. Andreeva, A. A. Moskalev, L. V. Omelyanchuk   +4 more
doaj  

Overexpression of Maize ZmMYB59 Gene Plays a Negative Regulatory Role in Seed Germination in Nicotiana tabacum and Oryza sativa

Frontiers in Plant Science, 2020
MYB transcription factors are involved in many biological processes, including metabolism, stress response and plant development. In our previous work, ZmMYB59 was down-regulated by deep sowing during maize seed germination.
Kaihui Zhai, Guangwu Zhao, Hongye Jiang, Caixia Sun, Jingyu Ren   +4 more
doaj   +1 more source