Results 81 to 90 of about 1,435,507 (315)

Enhanced Arabidopsis pattern-triggered immunity by overexpression of cysteine-rich receptor-like kinases

Frontiers in Plant Science, 2015
Upon recognition of microbe-associated molecular patterns (MAMPs) such as the bacterial flagellin (or the derived peptide flg22) by pattern-recognition receptors (PRRs) such as the FLAGELLIN SENSING2 (FLS2), plants activate the pattern-triggered immunity
Yu-Hung Yeh, Yuan-Hung Chang, Pin-Yao Huang, Jing-Bo Huang, L. Zimmerli   +4 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

Cancer Cell, 2014
SUMMARY UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, cultured cells and human tumors to demonstrate that UHRF1 is an oncogene.
Raksha Mudbhary, Y. Hoshida, Yelena Chernyavskaya, Vinitha Jacob, A. Villanueva, A. Villanueva, M. Fiel, Xintong Chen, K. Kojima, S. Thung, R. Bronson, A. Lachenmayer, K. Revill, Clara Alsinet, R. Sachidanandam, Anal Desai, S. Senbanerjee, C. Ukomadu, J. Llovet, K. Sadler   +19 more
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

, 2020
Objective Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance.
Martínez Valverde, Ángela María, Escalona Garrido, Carmen   +1 more
core   +1 more source

Overexpression of PAX5 in oral carcinogenesis

Oncology Reports, 2006
The oncogenic transcription factor PAX5 is an important developmental regulator and is implicated in the pathogenesis of several malignancies. The PAX5 gene is involved in medulloblastoma, non-Hodgkin's lymphoma, transitional cell carcinoma of the bladder, neuroblastoma, breast cancer and SCC.
Sufi, Norhany, Yukinao, Kouzu, Katsuhiro, Uzawa, Masayo, Hayama, Morihiro, Higo, Hirofumi, Koike, Atsushi, Kasamatu, Hideki, Tanzawa   +7 more
openaire   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis

PLoS ONE, 2015
Background Matrix metalloproteinases (MMPs) are regarded to be relevant to the prognosis of breast cancer. Numerous studies have confirmed the association between MMPs and tumor growth, invasion and metastasis in breast cancer.
Fanghui Ren, R. Tang, Xin Zhang, Wickramaarachchi Mihiranganee Madushi, Dianzhong Luo, Y. Dang, Zu-Yun Li, Kang-lai Wei, Gang Chen   +8 more
semanticscholar   +1 more source

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock

, 2012
Jean Charchaflieh,1,2 Georges I Labaze,1 Pulsar Li,1 Holly Van Remmen,3 Haekyung Lee,1 Helen Stutz,1 Arlan Richardson,3 Asher Emanuel,1 Ming Zhang1,41Department of Anesthesiology, State University of New York (SUNY) Downstate Medical Center, New York, NY,
Richardson A, Labaze GI, Van Remmen H, Li P, Lee H, Zhang M, Charchaflieh J, Emanuel A, Stutz H   +8 more
core  

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice [PDF]

, 2013
Aims/hypothesis: The NAD+-dependent protein deacetylase sirtuin (SIRT)1 is thought to be a key regulator of skeletal muscle metabolism. However, its precise role in the regulation of insulin sensitivity is unclear. Accordingly, we sought to determine the
White, Amanda T, Hamilton, David Lee, McCurdy, Carrie E, Philp, Andrew, Schenk, Simon, Johnson, Casey D   +5 more
core   +1 more source