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3D genome remodeling and homologous pairing during meiotic prophase of mouse oogenesis and spermatogenesis

Developmental Cell, 2023
During meiosis, the chromatin and transcriptome undergo prominent switches. Although recent studies have explored the genome reorganization during spermatogenesis, the chromatin remodeling in oogenesis and characteristics of homologous pairing remain ...
An Yan, Kehkooi Kee
exaly   +2 more sources

Homologous chromosome pairing in wheat

Journal of Cell Science, 1999
ABSTRACT Bread wheat is a hexaploid (AABBDD, 2n=6x=42) containing three related ancestral genomes, each having 7 chromosomes, giving 42 chromosomes in diploid cells. During meiosis true homologues are correctly associated in wild-type wheat, but a degree of association of related chromosomes (homoeologues) occurs in a mutant (ph1b).
E, Martínez-Pérez   +5 more
openaire   +2 more sources

Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1

Journal of Biochemistry (Tokyo), 2018
In eukaryotes, homologous recombination plays a pivotal role in both genome maintenance and generation of genetic diversity. Eukaryotic RecA homologues, RAD51 and DMC1, are key proteins in homologous recombination that promote pairing between homologous ...
W. Kobayashi   +5 more
semanticscholar   +1 more source

Phase separation drives pairing of homologous chromosomes

Current Genetics, 2020
Pairing of homologous chromosomes is crucial for ensuring accurate segregation of chromosomes during meiosis. Molecular mechanisms of homologous chromosome pairing in meiosis have been extensively studied in the fission yeast Schizosaccharomyces pombe.
Yasushi Hiraoka
exaly   +3 more sources

Homologous chromosome pairing

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1977
Abstract Commonly accepted precepts are challenged : (1) that homologous chromosome pairing is normally mediated by nuclear envelope attachment sites; (2) that crossover site establishment awaits synaptic completion; and (3) that it is the function of the synaptonemal complex to hold homologues in register so that equal crossing over ...
openaire   +2 more sources

Homologous pairing in vitro initiated by DNA synthesis

Biochemical and Biophysical Research Communications, 1990
A number of models have been proposed for the initiation of general genetic recombination. One of these, originally proposed by Meselson and Radding, imagines that the single-stranded 5' tail that results from strand displacement DNA repair synthesis can initiate homologous recombination by invading a homologous duplex.
T, Kodadek, M L, Wong
openaire   +2 more sources

Gene conversions and their relation to homologous chromosome pairing

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1986
Abstract Gene conversion is the non-reciprocal transfer of DNA sequences from one gene to a related gene elsewhere in the genome. Molecular evidence for its occurrence in higher eukaryotes was first described by our laboratory in 1980 in the two linked human foetal y-globin genes.
O, Smithies, P A, Powers
openaire   +2 more sources

The topology of homologous pairing promoted by RecA protein

Cell, 1980
In addition to catalyzing the pairing of linear single-stranded DNA with homologous duplex DNA, recA protein promotes the pairing of circular single strands with linear duplex DNA or nicked circular duplex DNA, and of gapped circular duplex DNA with superhelical DNA.
C, DasGupta   +3 more
openaire   +2 more sources

Simulation of chromosomal homology searching in meiotic pairing

Journal of Theoretical Biology, 1995
A cellular automaton model has been developed to simulate some aspects of chromosome behaviour during meiotic prophase when homologous chromosomes search for each other so that they can pair. Simulations allow one to compare the relative efficiencies of random searching by chromosome shuffling along the inner nuclear membrane or within the lumen of the
D, Dorninger, G, Karigl, J, Loidl
openaire   +2 more sources

OsDMC1 is required for homologous pairing in Oryza sativa

Plant Molecular Biology, 2007
OsDMC1 is the rice homologue of the yeast DMC1 gene. Here, we analyzed the function of OsDMC1 in meiosis using an RNA interference approach. The OsDMC1-RNAi lines grew normally during their vegetative phase but showed spikelet and pollen sterility.
Z. Deng, Tai Wang
semanticscholar   +3 more sources

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