Results 91 to 100 of about 789,870 (314)

Guidelines for identifying homologous recombination events in influenza A virus. [PDF]

PLoS ONE, 2010
The rapid evolution of influenza viruses occurs both clonally and non-clonally through a variety of genetic mechanisms and selection pressures. The non-clonal evolution of influenza viruses comprises relatively frequent reassortment among gene segments ...
Maciej F Boni, Menno D de Jong, H Rogier van Doorn, Edward C Holmes   +3 more
doaj   +1 more source

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast [PDF]

, 2013
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs).
AJ MacQueen, AL Goldstein, BH Lee, Bilge Argunhan, C Buhler, CY Bonilla, E Martini, EF Joyce, G Vader, H Sasanuma, H Sun, H Toyoizumi, H Tsubouchi, H-C Ho, H-Y Wu, HG Blitzblau, Hideo Tsubouchi, Hiroshi Toyoizumi, J Lange, JC Harrison, JE Haber, JL Gerton, KA Henderson, KS Tung, L Wan, L Xu, L Zou, M Lichten, M Lisby, M Petronczki, Michael Lichten, MJ Neale, Neil Humphryes, S Chu, S Farmer, S Farmer, S Keeney, Sarah Farmer, Tomomi Tsubouchi, Wing-Kit Leung, Yaroslav Terentyev   +40 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The many facets of homologous recombination at telomeres

Microbial Cell, 2015
The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctional telomere may resemble a DNA double-strand break (DSB), which is a severe form of DNA damage. The presence of one DSB is sufficient to
Clémence Claussin, Michael Chang
doaj   +1 more source

On a break with the X: the role of repair of double-stranded DNA breaks in X-linked disease [PDF]

, 2012
The problem of managing free reactive DNA ends in eukaryotic cells has resulted in the development of a number of mechanisms in order to ensure that free ends are rendered non-reactive, or that the double-strand DNA breaks generating the free ends are ...
Cecceroni, Lucia, De Caris, Laura, Tummala, Hemanth   +2 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

V_H replacement in rearranged immunoglobulin genes [PDF]

, 2005
Examples suggesting that all or part of the V_H segment of a rearranged V_HDJ_H may be replaced by all or part of another V_H have been appearing since the 1980s ...
Brokaw JL, Cascalho M, Choi Y, Chukwuocha RU, Covey LR, Cuomo CA, Deane M, Golub R, Han JO, Hesse JE, Kleinfield RW, Kobrin CB, Lewis SM, Ramsden DA, Rosenquist R, Shiokawa S, Sims GP, Steenbergen EJ, Steenbergen EJ, Taki S, Wasserman R, Wasserman R   +21 more
core   +2 more sources

Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

Nature Communications, 2017
BRCA1 and BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditary breast and ovarian cancer (HBOC).
N. Riaz, P. Blecua, R. Lim, R. Shen, D. Higginson, Nils Weinhold, L. Norton, B. Weigelt, S. Powell, J. Reis-Filho   +9 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +1 more source