Results 91 to 100 of about 345,396 (332)

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 [PDF]

, 2009
Homologous recombination (HR) and non‐homologous end joining (NHEJ) represent distinct pathways for repairing DNA double‐strand breaks (DSBs). Previous work implicated Artemis and ATM in an NHEJ‐dependent process, which repairs a defined subset of ...
Aaron A Goodarzi, Andrea Beucher, Andrea Krempler, Atsushi Shibata, Darroudi F, Julie Birraux, Leopoldine Tchouandong, Markus Löbrich, Olivia Barton, Penny A Jeggo, Sandro Conrad, Sonoda E, Taghian DG, Yuan SS   +13 more
core   +3 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +1 more source

Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.

PLoS Genetics, 2008
Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. BRCA2 maintains genome stability in part through the regulation of Rad51-dependent homologous recombination. Much about its precise function in
Martha Klovstad, Uri Abdu, Trudi Schüpbach   +2 more
doaj   +1 more source

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, EarlyView.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

Dynamics of male meiotic recombination frequency during plant development using Fluorescent Tagged Lines in Arabidopsis thaliana [PDF]

, 2017
Meiotic homologous recombination plays a central role in creating genetic variability, making it an essential biological process relevant to evolution and crop breeding.
De Storme, Nico, Geelen, Danny, Li, Fan
core   +1 more source

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

Advanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi, Jorge Romero Domínguez, Erol Hasan, Temur Maksudov, Thomas D. Anthopoulos, Dana Alsulaiman   +5 more
wiley   +1 more source

Genome characterization and population genetic structure of the zoonotic pathogen, streptococcus canis [PDF]

, 2012
Background - Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen.
Lang, P., Lefébure, T., Moroni, P., Pavinski Bitar, P.D., Richards, V.P., Stanhope, M.J., Tikofsky, L., Werner, B., Zadoks, R.N.   +8 more
core   +3 more sources

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, EarlyView.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase

G3: Genes, Genomes, Genetics, 2018
Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj   +1 more source