Results 181 to 190 of about 789,870 (314)

The role of homologous recombination in human retrovirus-associated diseases. [PDF]

Virus Genes
Akbarin MM, Farjami Z, Acevedo-Jiménez GE, Murillo CR, González-Fernández VD, de María Ávila-De la Vega L, Álvarez HR.   +6 more
europepmc   +1 more source

Evaluation of gene editing in CHO cells using the Cas‐CLOVER system

Biotechnology Progress, EarlyView.
Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah, Efecan Aral, Michael Hoffman, Jennifer Tedstone, Thomas King, Jason Vitko, Maria João Sebastião, Jose M. Escandell, Mafalda M. Dias, Iona McCall, Daniel Machado, Victor Cairns, Christine DeMaria, John J. Scarcelli   +13 more
wiley   +1 more source

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas. [PDF]

Int J Mol Sci
Iyevleva AG, Aleksakhina SN, Sokolenko AP, Otradnova EA, Nikitina AS, Kashko KA, Syomina MV, Shestakova AD, Kuligina ES, Morozova NS, Popov SV, Vyazovcev PV, Luchkova TY, Peremyshlenko AS, Topuzov TM, Gudkova OM, Orlova RV, Levushkin AV, Moiseev DO, Shkodenko ON, Gubarev DV, Dzyuba AV, Povorina IY, Agaeva AV, Kutyan VF, Grigoryan MM, Orlov AN, Lefterov SI, Belousov AV, Nechaeva MN, Vorobyeva EN, Amirkhanova IK, Kryukova NV, Zatulivetrova LI, Gomboeva AB, Krivtsov VN, Shchiglik OI, Prokudina NV, Butunina NA, Belyaev AM, Imyanitov EN.   +40 more
europepmc   +1 more source

Homologous Recombination [PDF]

, 2005
openaire   +1 more source

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Science Translational Medicine, 2017
Parker L. Sulkowski, C. Corso, Nathaniel D. Robinson, Susan E. Scanlon, K. Purshouse, Hanwen Bai, Yanfeng Liu, R. Sundaram, D. Hegan, N. Fons, Gregory A. Breuer, Yuanbin Song, Ketu Mishra-Gorur, Henk M. de Feyter, R. D. de Graaf, Y. Surovtseva, M. Kachman, Stephanie Halene, Murat Günel, P. Glazer, R. Bindra   +20 more
semanticscholar   +1 more source

A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl‐Aryl Ether Formation in the Biosynthesis of Emestrin

Chemistry – A European Journal, EarlyView.
Conversion of emestrin J (5) to emestrin (1) by three P450 enzymes from the cluster (eme) in Emericella quadrilineata. EmeO acts as a bifunctional enzyme for the construction of the 15‐membered lactone ring via an aryl‐aryl ether bond formation and simultaneous hydroxylation between phenolic and nonphenolic aromatic rings, while EmeE and EmeR install ...
Yu‐Chuan Chen, Jing‐Jing Wu, Ming‐Hua Chen, Shu‐Ming Li   +3 more
wiley   +1 more source

Homologous Recombination in Thyroid Tumor Samples. [PDF]

Int J Mol Sci
Spirina LV, Tsyganov MM, Chizhevskaya SY, Tarasenko NV, Bogdanova VA.   +4 more
europepmc   +1 more source

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Nature Genetics, 2017
P. Polak, Jaegil Kim, L. Braunstein, R. Karlić, Nicholas J Haradhavala, G. Tiao, D. Rosebrock, D. Livitz, Kirsten Kübler, K. Mouw, A. Kamburov, Y. Maruvka, I. Leshchiner, E. Lander, T. Golub, A. Zick, Alexandre Orthwein, M. Lawrence, R. Batra, C. Caldas, D. Haber, P. Laird, Hui Shen, L. Ellisen, A. D’Andrea, S. Chanock, W. Foulkes, G. Getz   +27 more
semanticscholar   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

The expanding roles of homologous recombination proteins in genome stability. [PDF]

EMBO J
Sassi L, Martinez Marroquin A, Waked S, Ardizzoia A, Costanzo V.   +4 more
europepmc   +1 more source