Angewandte Chemie International Edition, Accepted Article.Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically and ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering.
Martin Baunach +6 more
wiley +1 more source
Homologous pairing in genetic recombination: complexes of recA protein and DNA.
, 1979 Takahiro Shibata +3 more
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Homologous sequences other than insertion elements can serve as recombination sites in plasmid drug resistance gene amplification [PDF]
, 1983 Brian C. Peterson, R H Rownd
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Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2-acetylaminofluorene. [PDF]
, 1984 C Luisi-DeLuca +2 more
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Angewandte Chemie International Edition, Accepted Article.DNA four‐way junctions (4WJs) play an important biological role in DNA repair and recombination, and viral regulation, and are attractive therapeutic targets. Compounds that recognise the junction structure are rare; in this work, we describe cationic metallo‐supramolecular M2L4 cages as a new type of 4WJ binder with nanomolar affinities. A combination
Samuel J. Dettmer +6 more
wiley +1 more source
Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin
IJU Case Reports, Volume 6, Issue 1, Page 37-40, January 2023., 2023 Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose) polymerase inhibitors such as olaparib.
Yoshiyuki Miyazawa +9 more
wiley +1 more source
Homologous recombination between transferred and chromosomal immunoglobulin kappa genes. [PDF]
, 1988 Mark D. Baker, Marc J. Shulman
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Recent Advances in Nitride‐Based Micro‐LEDs for Next‐Generation Display
Advanced Physics Research, EarlyView.Nitride‐based Micro‐light‐emitting diode (Micro‐LED) is now spreading into the field of display technology, which has been dominated by liquid crystal display (LCD) and organic LED (OLED). This review focuses on recent developments in Micro‐LED display, including epitaxy and chip processing, mass transfer, driving, bonding, and detection technologies ...
Jiahao Song +9 more
wiley +1 more source
Homologous Recombination and the Repair of Double-Strand Breaks During Cotransformation of Dictyostelium discoideum [PDF]
, 1988 Kenneth Katz, David I. Ratner
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Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
doaj +1 more source