Results 191 to 200 of about 341,184 (291)

Homologous Recombination Deficiency in Skin Cancers: Prevalence and Clinical Implications of This Distinct Patient Cohort. [PDF]

JCO Precis Oncol
Nassief G, Adeyelu T, Elliott A, Phillipps J, Morecroft R, Zhou AY, Szlosarek PW, Robert C, Abdulla F, Vanderwalde A, Park SJ, Chen D, Ansstas G.   +12 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer. [PDF]

Commun Med (Lond)
Davies HR, Black D, Kvist A, Sigurjónsdóttir K, Bosch A, Bowden R, Memari Y, Chen Z, Rinaldi G, Rosengren F, Nacer DF, Veerla S, Hohmann L, Nordborg N, Häkkinen J, Vallon-Christersson J, Borg Å, Nik-Zainal S, Staaf J.   +18 more
europepmc   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma. [PDF]

J Biol Chem
Ghosh A, Ray P, Thomas D, Jeeyar V, Pillai S, Basrur V, Bondarenko IV, Bellile E, Wang DH, Morgan MA, Zhang Q, Beer DG, Lagisetty KH, Lawrence TS, Ray D.   +14 more
europepmc   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

Telmisartan increases olaparib efficacy in homologous recombination proficient tumors by augmenting type I interferon production. [PDF]

J Immunother Cancer
Murray CE, Ontiveros CO, Wentworth J, Blinkiewicz P, Leung B, Bai H, Spicer N, Holtz A, Tanner C, Balasubramanian A, Li W, Dray E, Zhao W, Curiel TJ.   +13 more
europepmc   +1 more source

RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer. [PDF]

NPJ Breast Cancer
Llop-Guevara A, Pellegrino B, Pimentel I, Villacampa G, Solinas C, Torres-Esquius S, Campanini N, Simonetti S, Tommasi C, Serra O, Corianò M, Boggiani D, Michiara M, Minari R, Bortesi B, Rapacchi E, Dieci MV, Lambertini M, Zoppoli G, Schirone A, Casarini C, Cretella E, Cortesi L, Silini EM, Saura C, Willard-Gallo K, Boisson A, Musolino A, Serra V, Balmaña J, Cruz C.   +30 more
europepmc   +1 more source