Results 191 to 200 of about 210,282 (254)

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial. [PDF]

Nat Med
Park W, O'Connor CA, Chou JF, Hilmi M, Tarcan Z, Schwartz C, Larsen M, Homsi R, Sivaprakasam K, Umeda S, Perry MA, Varghese AM, Yu KH, Balogun F, Zervoudakis A, Katz SS, Kim TH, Zhao K, Richards AL, Lecomte N, Martin Muldoon D, Karnoub E, Chatila W, Yang J, El-Dika I, Rao D, Joshi S, Foote MB, Sugarman R, Harding JJ, Epstein AS, Kelsen D, Chalassani S, Keane F, Schoenfeld JD, Singhal A, Diguglielmo E, Bandlamudi C, Song J, Ozkan HS, Hong J, Zhang H, Cardenas AI, Lao M, Melchor J, Shah R, Kang W, Mazzoni F, Soares K, Donoghue MT, Santos E, Rolston V, Reyngold M, Wei AC, Tipping M, Basturk O, Berger M, Kihn Do R, Schattner M, Jarnagin WR, Riaz N, Balachandran V, Pe'er D, Capanu M, Iacobuzio-Donahue C, O'Reilly EM.   +65 more
europepmc   +1 more source

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer. [PDF]

Commun Med (Lond)
Davies HR, Black D, Kvist A, Sigurjónsdóttir K, Bosch A, Bowden R, Memari Y, Chen Z, Rinaldi G, Rosengren F, Nacer DF, Veerla S, Hohmann L, Nordborg N, Häkkinen J, Vallon-Christersson J, Borg Å, Nik-Zainal S, Staaf J.   +18 more
europepmc   +1 more source

Materials and Music: Selective Imperfection as a Generative Framework for Analysis, Creativity and Discovery

Interdisciplinary Materials, EarlyView.
Vibrations in matter, from spider webs to molecules, water to flames, share a grammar with music. We propose that creativity emerges when constraints force expansion beyond existing possibilities. Selective imperfection restores balance, enabling invention.
Markus J. Buehler
wiley   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort. [PDF]

Commun Med (Lond)
Al Assaad M, Hadi K, Levine MF, Guevara D, Patel M, Tranquille M, King A, Otilano J, Semaan A, Gundem G, Medina-Martínez JS, Sigouros M, Manohar J, Kuo HH, Wilkes DC, Andreopoulou E, Chapman-Davis E, Tagawa ST, Sboner A, Ocean AJ, Shah MA, Papaemmanuil E, Sternberg CN, Holcomb K, Nanus DM, Elemento O, Mosquera JM.   +26 more
europepmc   +1 more source

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

International Journal of Cancer, EarlyView.
ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia, Daniele Santini, Marc R. Matrana, Marco Maruzzo, Ray Manneh Kopp, Lorenzo Antonuzzo, Sergio Bracarda, Deniz Tural, Giuseppe Procopio, Maria T. Bourlon, Orazio Caffo, Martin Ignacio Zapata Laguado, Massimo Di Maio, Brigida Anna Maiorano, Vincenza Conteduca, Sabrina Rossetti, Helga Lipari, Thomas Büttner, Mimma Rizzo, Yüksel Ürün, Carlo Messina, Fernando Sabino Marques Monteiro, Andrey Soares, Mattia Puglisi, Alice Principi, Eleonora Lai, Giulia Mammone, Marco Stellato, Ilaria Depetris, Tancredi Didier Bazan Russo, Isadora Yasbick Spricido, Camila Bobato Lara Gismondi, Francesco Massari, Nicola Pavan, Matteo Santoni, Tarek Taha   +35 more
wiley   +1 more source

ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma. [PDF]

J Biol Chem
Ghosh A, Ray P, Thomas D, Jeeyar V, Pillai S, Basrur V, Bondarenko IV, Bellile E, Wang DH, Morgan MA, Zhang Q, Beer DG, Lagisetty KH, Lawrence TS, Ray D.   +14 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source