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Mobilization of the AbGRI4 resistance island in <i>Acinetobacter baumannii</i>: IS<i>26</i> action and homologous recombination both contribute. [PDF]

Microbiol Spectr
Harmer CJ, Kenyon JJ, Hall RM.
europepmc   +1 more source

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Innovation by homologous recombination

Current Opinion in Chemical Biology, 2013
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L., Smith, Matthew A., Arnold, Frances H.   +2 more
openaire   +3 more sources

Hotspots of homologous recombination

Experientia, 1994
Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
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Homologous Recombination in Eukaryotes

2012
Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Ravindra, Amunugama, Richard, Fishel
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Biochemistry of eukaryotic homologous recombination

2006
The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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Mechanism of Eukaryotic Homologous Recombination

Annual Review of Biochemistry, 2008
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Joseph, San Filippo, Patrick, Sung, Hannah, Klein   +2 more
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Homologous recombination as a mechanism of carcinogenesis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2001
Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones.
A J, Bishop, R H, Schiestl
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Homologous recombination

Experientia, 1994
W D, Heyer, J, Kohli
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Mechanisms for homologous recombination

Nature, 1985
A, Nicolas, J L, Rossignol
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RNA transcripts stimulate homologous recombination by forming DR-loops

Nature, 2021
Jiamin Zhang, Esther Rheinbay, Li Lan
exaly