Results 231 to 240 of about 233,309 (305)

Development of a lactate metabolism signature for predicting homologous recombination repair status in breast cancer. [PDF]

Sci Rep
Lin Y, Jiang L, Hu S, Zhang Y, Luo M.
europepmc   +1 more source

From Metabolic Crisis to Molecular Classification: Multidisciplinary Management of Synchronous Endometrioid Ovarian and Endometrial Carcinomas With Massive Tumor Burden

Cancer Nexus, EarlyView.
Managing massive tumor burden in synchronous endometrioid carcinomas. The graphical abstract summarizes the clinical pathway from presentation with massive ascites, pleural effusion, and critical metabolic abnormalities to multidisciplinary stabilization, surgical management, integrated morphologic–molecular classification, and shared decision‐making ...
Anna Homeniuk, Leena Abdalla, Sharon Fitzgerald   +2 more
wiley   +1 more source

Prevalence and spectrum of homologous recombination repair mutations in patients with metastatic prostate cancer from India. [PDF]

Oncologist
Baskarane H, Jain R, Divakar MK, Seth A, Nayak B, Bakhshi S, Sahoo RK, Kumar A, Sharma A, Kaushal S, Haresh KP, Hooda V, Vasudeva P, Singh PP, Agarwal R, Vasundhara S, Agarwal N, Batra A.   +17 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Dynamic changes in homologous recombination status before and after chemotherapy in advanced ovarian, fallopian tube, and primary peritoneal cancers. [PDF]

J Ovarian Res
Morimoto A, Matsumoto T, Teramoto N, Murakami S, Usami T, Murai J, Sugiyama T.   +6 more
europepmc   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

EXPRESSION OF CONCERN: Overexpression of TNKS1BP1 in Lung Cancers and Its Involvement in Homologous Recombination Pathway of DNA Double-Strand Breaks. [PDF]

Cancer Med
europepmc   +1 more source

The Potential of DNA Polymerase Theta (POLQ) Inhibitors as Cancer Therapy for Homologous Recombination (HR)-Deficient Tumors. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair-deficient breast or ovarian cancer. [PDF]

BJC Rep
Camacho-Valenzuela J, Matis T, Roca C, Cuamatzi Flores JL, Hamel N, Rivera B, Gravel S, Polak P, Robles-Espinoza CD, Foulkes WD.   +9 more
europepmc   +1 more source