Results 231 to 240 of about 341,184 (291)

Resistance of Botrytis cinerea to anilinopyrimidine fungicides: A novel ARMS‐PCR method for the detection of Bcpos5 mutations and characterization of resistance using CRISPR/Cas9 editing

Pest Management Science, EarlyView.
A TETRA‐primer amplification refractory mutation system polymerase chain reaction (T‐ARMS‐PCR) method was developed for simultaneous detection of the L412F/V and G408V mutations. L412F/V mutants were created using the CRISPR/Cas tool and no fitness cost was observed.
Georgios Sofianos, Athanasios Petmezas, Anastasios Samaras, George Karaoglanidis   +3 more
wiley   +1 more source

Predicting homologous recombination deficiency and treatment responses using a computed tomography-based foundation model: a preclinical study. [PDF]

NPJ Precis Oncol
Kuang S, Schuitmaker L, Wu M, Salahuddin Z, van der Wiel A, van de Laak J, Lieuwes N, Biemans R, Jung J, Yaromina A, Dubois LJ, Woodruff HC, Lambin P.   +12 more
europepmc   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility. [PDF]

Br J Cancer
Vlachos G, Moser T, Lazzeri I, Moser MJ, Glawitch L, Bauernhofer ET, Eberhard A, Beichler C, Sadeghi H, Blatterer J, Kühberger S, Monsberger N, Terbuch A, Kashofer K, Geigl JB, Bauernhofer T, Heitzer E.   +16 more
europepmc   +1 more source

Orthogonal Tri‐Modular Coiled‐Coil Assembly for Programmable Multi‐Cargo Display on Escherichia coli Nissle 1917

Small, EarlyView.
A tri‐specific scaffold cell (TriSC) platform is engineered to enable programmable, reversible, and multiplex surface assembly through orthogonal and spontaneous coiled‐coil interactions. Independent targeting and therapeutic nanobodies are modularly recruited onto bacterial surfaces, allowing tunable combinatorial functionality.
Yong Joon Cho, Gyu‐Jin Lee, Jong‐Ha Park, Sung In Lim   +3 more
wiley   +1 more source

SOHLH2-RAD54L axis induces radioresistance by promoting homologous recombination repair in non-small cell lung cancer. [PDF]

Cell Death Discov
Yang JX, Zhang WH, Lei JJ, Cheng C, Yu M, Zhang P, Sang Y.   +6 more
europepmc   +1 more source

Information Dynamics and Learning in Complex Adaptive Systems: Toward a Transdisciplinary Framework

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This article develops a framework for understanding learning and adaptation in complex adaptive systems. Drawing from neuroscience, systems theory, information theory and quantum field theory, it examines how information processing, plasticity and systemic coherence emerge from distributed, nonlinear and feedback‐driven interactions. It argues
Anderson de Souza Sant'Anna
wiley   +1 more source

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair-associated gene alterations in solid tumors from a large Asian cohort. [PDF]

BMC Cancer
Ren L, Yao R, Hou T, Liu C, Zhao F, Chen X, Zhang Z, Huang Y.   +7 more
europepmc   +1 more source

Constitutional BRCA1 Methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer. [PDF]

NPJ Breast Cancer
Pasanisi J, Lamy C, Lecompte L, Vacher S, Schwartz M, Hamza A, Caputo SM, Ibadioune S, Courtois L, Berger F, Cockenpot V, Baulande S, Pierga JY, Callens C, Melaabi S, Colas C, Pasmant E, Kamal M, Dupain C, Servant N, Le Tourneau C, Bièche I.   +21 more
europepmc   +1 more source

Homologous Recombination Deficiency Testing in Women With Ovarian Cancer: An Egyptian Multicentre Study. [PDF]

BJOG
Shohdy KS, Kassem L, Gabriel B, Barsoum E, Elnahas T, Azim HA.   +5 more
europepmc   +1 more source