Results 241 to 250 of about 233,309 (305)

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

Targeting IP₆ signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance. [PDF]

Nat Commun
Lee SG, Seo Y, Jeong S, Chung Y, Kong S, Kim M, Rhlee JH, Um S, Mathew BP, Maiti S, Kuram MR, Abozeid MA, Park A, Yoo JN, Khim KW, Son K, Amarsanaa E, Kim K, Hong S, Choi J, Park IB, Lee EA, Jeon JH, Park JH, Han JS, Park CY, Kim S, Choi JH, Hong SY, Seo MD, Lee H, Lee JY, Myung K.   +32 more
europepmc   +1 more source

Dual Ferro‐/Piezo‐Electric Coupling in Two‐Dimensional [Bi2O2]‐Based Layered Structures for Synergistic Harvesting of Mechanical and Solar Energy

Exploration, EarlyView.
Inter‐plane 2D/2D nanosheet heterojunction based on two piezoelectric [Bi2O2]‐based layered compounds is constructed. Significantly increased piezoelectric properties of BiOBr@Bi5Ti3FeO15 by morphological regulation and interface chemical bonds. Dual‐piezoelectric field can modulate interfacial electric field and the interfacial band bending to ...
Daotong You, Xingwang Long, Zhiyong Yang, Lei Liu, Jianbang Chen, Tuan Guo   +5 more
wiley   +1 more source

Homologous Recombination Deficiency in Skin Cancers: Prevalence and Clinical Implications of This Distinct Patient Cohort. [PDF]

JCO Precis Oncol
Nassief G, Adeyelu T, Elliott A, Phillipps J, Morecroft R, Zhou AY, Szlosarek PW, Robert C, Abdulla F, Vanderwalde A, Park SJ, Chen D, Ansstas G.   +12 more
europepmc   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial. [PDF]

Nat Med
Park W, O'Connor CA, Chou JF, Hilmi M, Tarcan Z, Schwartz C, Larsen M, Homsi R, Sivaprakasam K, Umeda S, Perry MA, Varghese AM, Yu KH, Balogun F, Zervoudakis A, Katz SS, Kim TH, Zhao K, Richards AL, Lecomte N, Martin Muldoon D, Karnoub E, Chatila W, Yang J, El-Dika I, Rao D, Joshi S, Foote MB, Sugarman R, Harding JJ, Epstein AS, Kelsen D, Chalassani S, Keane F, Schoenfeld JD, Singhal A, Diguglielmo E, Bandlamudi C, Song J, Ozkan HS, Hong J, Zhang H, Cardenas AI, Lao M, Melchor J, Shah R, Kang W, Mazzoni F, Soares K, Donoghue MT, Santos E, Rolston V, Reyngold M, Wei AC, Tipping M, Basturk O, Berger M, Kihn Do R, Schattner M, Jarnagin WR, Riaz N, Balachandran V, Pe'er D, Capanu M, Iacobuzio-Donahue C, O'Reilly EM.   +65 more
europepmc   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer. [PDF]

Commun Med (Lond)
Davies HR, Black D, Kvist A, Sigurjónsdóttir K, Bosch A, Bowden R, Memari Y, Chen Z, Rinaldi G, Rosengren F, Nacer DF, Veerla S, Hohmann L, Nordborg N, Häkkinen J, Vallon-Christersson J, Borg Å, Nik-Zainal S, Staaf J.   +18 more
europepmc   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source

ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma. [PDF]

J Biol Chem
Ghosh A, Ray P, Thomas D, Jeeyar V, Pillai S, Basrur V, Bondarenko IV, Bellile E, Wang DH, Morgan MA, Zhang Q, Beer DG, Lagisetty KH, Lawrence TS, Ray D.   +14 more
europepmc   +1 more source