Results 241 to 250 of about 341,184 (291)

MDS/AML-associated DDX41 helicase facilitates homologous recombination repair by potentially resolving R-loops. [PDF]

Nucleic Acids Res
Aggarwal A, Yang S, Winstone L, Mondal S, Grainger H, Singh RS, Arna AB, Vizeacoumar FJ, Wu Y.   +8 more
europepmc   +1 more source

Analytical validation of a homologous recombination deficiency signature (HRDsig) in pan-tumor tissue samples. [PDF]

PLoS One
Li W, Leibowitz JA, Wang S, Walker L, Xu C, Chen KT, Schrock AB, Hughes J, Patel N, Elvin JA, Ritterhouse LL, Sokol E, Frampton G, Dennis L, Yilmazel B, Decker B.   +15 more
europepmc   +1 more source

CRISPR herd immunity against a transducing phage underlies adaptive homologous recombination in resting bacteria

Payne P, Plevka P, Bollback JP, Guet CC.
europepmc   +1 more source

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Innovation by homologous recombination

Current Opinion in Chemical Biology, 2013
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L., Smith, Matthew A., Arnold, Frances H.   +2 more
openaire   +3 more sources

Homologous Recombination in Eukaryotes

2012
Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Ravindra, Amunugama, Richard, Fishel
openaire   +2 more sources

Hotspots of homologous recombination

Experientia, 1994
Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
openaire   +2 more sources

Mechanism of Eukaryotic Homologous Recombination

Annual Review of Biochemistry, 2008
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Joseph, San Filippo, Patrick, Sung, Hannah, Klein   +2 more
openaire   +2 more sources

Homologous recombination

Experientia, 1994
W D, Heyer, J, Kohli
openaire   +4 more sources

Genetic Engineering Using Homologous Recombination

Annual Review of Genetics, 2002
▪ Abstract  In the past few years, in vivo technologies have emerged that, due to their efficiency and simplicity, may one day replace standard genetic engineering techniques. Constructs can be made on plasmids or directly on the Escherichia coli chromosome from PCR products or synthetic oligonucleotides by homologous recombination.
Donald L, Court, James A, Sawitzke, Lynn C, Thomason   +2 more
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Gene Replacement by Homologous Recombination

2019
While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Henner, Zirpel, Joachim, Clos
openaire   +2 more sources