Results 271 to 280 of about 348,739 (321)

CRISPR herd immunity against a transducing phage underlies adaptive homologous recombination in resting bacteria

Payne P, Plevka P, Bollback JP, Guet CC.
europepmc   +1 more source

Homologous recombination shapes the architecture and evolution of bacterial genomes. [PDF]

Nucleic Acids Res
Torrance EL, Diop A, Bobay LM.
europepmc   +1 more source

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

International Journal of Cancer, EarlyView.
What's New? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M. Piskorz, Robert Brown, James D. Brenton, Iain A. McNeish, James M. Flanagan   +7 more
wiley   +1 more source

A Novel Droplet Digital PCR Assay for BRCA1 and RAD51C Methylation: Advancing Homologous Recombination Deficiency Detection in Ovarian Cancer. [PDF]

J Mol Diagn
Michel C, Simon A, Witz A, Hanriot I, Dardare J, Betz M, Brun M, Gilson P, Merlin JL, Harlé A.   +9 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration. [PDF]

Front Cell Dev Biol
Sugiyama R, Sedukhina AS, Sato E, Yamaura A, Minagawa K, Pae S, Imai E, Chawla A, Xu Z, Chakraborty M, Gonoi S, Yamaoka J, Yudo K, Tsugawa K, Sato K.   +14 more
europepmc   +1 more source

Incidentally Detected Ductal Adenocarcinoma Presenting With Isolated Pulmonary Metastasis and a BRCA2 Mutation

IJU Case Reports, EarlyView.
ABSTRACT Background Ductal adenocarcinoma of the prostate is a rare and aggressive cancer that often presents with low prostate‐specific antigen levels and nonspecific urinary symptoms, leading to a delayed diagnosis. Mutations in DNA repair genes such as BRCA2 may render these cancers susceptible to targeted treatments. Case Presentation A 78‐year‐old
Hiroyuki Karasawa, Takeo Kosaka, Akari Komatsuda, Yuto Baba, Kohei Nakamura, Hiroshi Nishihara, Mototsugu Oya   +6 more
wiley   +1 more source

Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNA. [PDF]

Nucleic Acids Res
Chanteau A, Quilleré S, Crouset A, Allipra S, Tuquoi U, Perroud PF, Miron S, Dupaigne P, Zinn-Justin S, Nogué F, Kumar R.   +10 more
europepmc   +1 more source

Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination [PDF]

, 2007
H. Nagasawa, Paul F. Wilson, D J Chen, L.H. Thompson, Joel S. Bedford, J B Little   +5 more
openalex  

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

iMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu, Li‐Ting Chen, Xu‐Ying Pei, Shao‐Nan Hu, Fang‐Fang Zhuo, Ze‐Kun Chen, Yang Liu, Jing‐Kang Wang, Ji‐Chao Zhang, Qi Cao, Ling Li, Jing Wang, Tian‐Tian Wei, Bo Han, Peng‐Fei Tu, Xiang‐Yu Zhao, Ruidong Xue, Ke‐Wu Zeng   +17 more
wiley   +1 more source