Results 261 to 270 of about 233,309 (305)

Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer. [PDF]

Proc Natl Acad Sci U S A
Traphagen NA, Wheeler E, Li R, Akhshi T, Ravindranathan R, Alfieri C, Lu F, Ahmed B, Tewari AK, Balk SP, Nelson PS, Corey E, Long H, D'Andrea AD, Qiu X, Brown M.   +15 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma. [PDF]

Cell Death Dis
Onishi S, Jayamohan S, Chowdhury A, Rivas S, Otani Y, Ertekin C, Bryant JP, Murphy SA, Rivera-Caraballo KA, Walbridge S, Sisay B, Maric D, Elkahloun A, Johnson K, Brown DA, Heiss JD, Shah AH, Lee TJ, Kumbar SG, Yoo JY, Brenner AJ, Kaur B, Sareddy GR, Banasavadi-Siddegowda YK.   +23 more
europepmc   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair. [PDF]

Occup Health (Auckl)
Williams AR, Meaza I, Lu H, Wise JTF, Diven SS, Toyoda JH, Kouokam JC, Wise JP.   +7 more
europepmc   +1 more source

Mobilization of the AbGRI4 resistance island in <i>Acinetobacter baumannii</i>: IS<i>26</i> action and homologous recombination both contribute. [PDF]

Microbiol Spectr
Harmer CJ, Kenyon JJ, Hall RM.
europepmc   +1 more source

Prevalence of Homologous Recombination Deficiency and Treatment Patterns in Patients with Newly Diagnosed Advanced Ovarian Cancer in Bulgaria: A Real-World Cohort Study (VALIDATE). [PDF]

Medicina (Kaunas)
Arabadjiev J, Nikolov K, Koleva M, Shopov N, Tonev I, Krasteva R, Donev I, Yordanov V, Minchev V, Konsoulova A.   +9 more
europepmc   +1 more source

Daxx-Dependent H3.3 Deposition Promotes Double-Strand Breaks Repair by Homologous Recombination. [PDF]

Cells
Zannini L, Aliprandi S, Delia D, Buscemi G.   +3 more
europepmc   +1 more source

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Innovation by homologous recombination

Current Opinion in Chemical Biology, 2013
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L., Smith, Matthew A., Arnold, Frances H.   +2 more
openaire   +3 more sources