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Homologous Recombination in Eukaryotes
2012Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Ravindra, Amunugama, Richard, Fishel
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Hotspots of homologous recombination
Experientia, 1994Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
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Biochemistry of eukaryotic homologous recombination
2006The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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Mechanism of Eukaryotic Homologous Recombination
Annual Review of Biochemistry, 2008Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Joseph, San Filippo +2 more
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Homologous recombination as a mechanism of carcinogenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2001Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones.
A J, Bishop, R H, Schiestl
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Homologous Recombination—Enzymes and Pathways
EcoSal Plus, 2012Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA damage. The reaction is classically divided into three phases: presynaptic, synaptic, and postsynaptic. In Escherichia coli , the presynaptic phase involves either RecBCD or RecFOR proteins, which act on DNA double-stranded ends ...
Bénédicte, Michel, David, Leach
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Homologous recombination in a mammalian plasmid
Molecular and General Genetics MGG, 1990Bovine papillomavirus (BPV) shuttle vectors replicate as a circular plasmid in mouse cell nuclei without impairing host cell viability. We used these vectors to analyze homologous recombination in mammalian cells. When several BPV-based plasmids carrying direct repeats were introduced into C127 cells, we detected many recombinant plasmid molecules that
Y, Kitamura, H, Yoshikura, I, Kobayashi
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Homologous Recombination in Plants: An Antireview
2010Homologous recombination (HR) is a central cellular process involved in many aspects of genome maintenance such as DNA repair, replication, telomere maintenance, and meiotic chromosomal segregation. HR is highly conserved among eukaryotes, contributing to genome stability as well as to the generation of genetic diversity.
Michal, Lieberman-Lazarovich +1 more
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Involvement of Homologous Recombination in Carcinogenesis
2007DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, evidence is accumulating that deleterious genomic rearrangements can result from HR. It therefore follows that HR events may play a causative role in carcinogenesis.
Ramune, Reliene +2 more
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