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Genetic Engineering Using Homologous Recombination
Annual Review of Genetics, 2002▪ Abstract In the past few years, in vivo technologies have emerged that, due to their efficiency and simplicity, may one day replace standard genetic engineering techniques. Constructs can be made on plasmids or directly on the Escherichia coli chromosome from PCR products or synthetic oligonucleotides by homologous recombination.
Donald L, Court +2 more
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Gene Replacement by Homologous Recombination
2019While homologous recombination-based gene replacement is about to be supplanted by more modern approaches, it is still retaining usefulness for genes that prove to be poor targets for CRISPR/cas-based approaches. Homologous recombination has proven to be relatively robust to minor sequence mismatches between GOI-flanking sequences and the gene ...
Henner, Zirpel, Joachim, Clos
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Biochemistry of eukaryotic homologous recombination
2006The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout ...
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Detecting the mutational signature of homologous recombination deficiency in clinical samples
Nature Genetics, 2019D. Gulhan +4 more
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Mechanisms for homologous recombination
Nature, 1985A, Nicolas, J L, Rossignol
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