Results 291 to 300 of about 345,396 (332)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Homologous recombination deficiency testing in ovarian cancer: the diagnostic experience of a referral Italian institution. [PDF]

Pathologica
Pepe F, Russo G, Cefaliello A, Lamia MR, Buonaiuto R, Crimaldi G, Scimone C, Palumbo L, Roscigno G, Parente P, De Finis MC, Fiordelisi F, Marchetti C, Giampaolino P, De Angelis C, Bianco R, Troncone G, Malapelle U.   +17 more
europepmc   +1 more source

Correction: Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition. [PDF]

Br J Cancer
Bellare GP, Saha B, Patro BS.
europepmc   +1 more source

Autophagy induction enhances homologous recombination-associated CRISPR-Cas9 gene editing. [PDF]

Nucleic Acids Res
Nam HJ, Han JH, Yu J, Cho CS, Kim D, Kim YE, Kim MJ, Kim JH, Jo DH, Bae S.   +9 more
europepmc   +1 more source

Combination of <i>BRCA</i> deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer. [PDF]

Front Oncol
Nguyen Hoang TP, Tran NHB, Nguyen TA, Ngo MTT, Doan AD, Nguyen DQ, Tang HS, Nguyen DS, Thi CTN, Thi TTD, Nguyen HN, Giang H, Tu LN.   +12 more
europepmc   +1 more source

DirectHRD enables sensitive scar-based classification of homologous recombination deficiency. [PDF]

Nucleic Acids Res
Liu R, Roberts E, Parsons HA, Stover EH, Choudhury AD, Rhoades J, Blewett T, Yang DD, Liu JF, Mayer EL, Adalsteinsson VA.   +10 more
europepmc   +1 more source

Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer. [PDF]

JCO Precis Oncol
Christinat Y, Labidi-Galy I, Ho L, Clément S, Genestie C, Sehouli J, Cinieri S, Gonzalez-Martin A, Kolovetsiou-Kreiner V, Fujiwara K, Von Gorp T, Tognon G, Hietanen S, Heinzelmann-Schwarz V, Ray-Coquard I, Pujade-Lauraine E, McKee TA.   +16 more
europepmc   +1 more source

CRISPR-Cas targeting in Haloferax volcanii promotes within-species gene exchange by triggering homologous recombination

Choudhary DK, Turgeman-Grott I, Robinzon S, Gophna U.   +3 more
europepmc   +1 more source