Results 291 to 300 of about 651,783 (359)

A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer. [PDF]

J Exp Clin Cancer Res
Calheiros J, Silva R, Barbosa F, Morais J, Moura SR, Almeida S, Fiorini E, Mulhovo S, Aguiar TQ, Wang T, Ricardo S, Almeida MI, Domingues L, Melo SA, Corbo V, Ferreira MU, Saraiva L.   +16 more
europepmc   +1 more source

Competence induction of homologous recombination genes protects pneumococcal cells from genotoxic stress. [PDF]

mBio
De Lemos D, Soulet A-L, Morales V, Berge M, Polard P, Johnston C.   +5 more
europepmc   +1 more source

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, EarlyView.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection. [PDF]

Nat Commun
Fu H, Huang M, Wu H, Zheng H, Gong Y, Xing L, Gong J, An R, Li Q, Jie X, Ma X, Tang TS, Guo C.   +12 more
europepmc   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. [PDF]

Sci Adv
Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y.   +12 more
europepmc   +1 more source

Production of hydroxyectoine from biogas by an engineered strain of Methylomicrobium alcaliphilum using a novel Taylor‐flow bioreactor

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The production of compatible solutes, such as ectoine and hydroxyectoine, is of great interest due to their industrial and biotechnological applications. Methylomicrobium alcaliphilum was genetically engineered to replace a native gene with a heterologous one, aiming to enhance ectoine production.
Raquel Herrero‐Lobo, Nuria Fernández‐González, Eva Marcos, María Alejandra Martínez, Pedro García‐Encina, María del Rosario Rodero, Raúl Muñoz, Sergio Bordel   +7 more
wiley   +1 more source

Microbial species and intraspecies units exist and are maintained by ecological cohesiveness coupled to high homologous recombination. [PDF]

Nat Commun
Conrad RE, Brink CE, Viver T, Rodriguez-R LM, Aldeguer-Riquelme B, Hatt JK, Venter SN, Rossello-Mora R, Amann R, Konstantinidis KT.   +9 more
europepmc   +1 more source

The Clinical Pathological Characteristics and Prognostic Relevance of Homologous Recombination Repair Gene Mutations in Ovarian Cancer Patients: A Prospective Cohort Study. [PDF]

Obstet Gynecol Int
Zhan S, Chen F, Huang L, Chen L, Jia H, Ma S, Tang M, Zhou C, Chen Y, Yang Y.   +9 more
europepmc   +1 more source

EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Chronic infection with the hepatitis B virus (HBV) remains one of the primary drivers of the development of hepatocellular carcinoma (HCC), a highly aggressive malignancy with a grim prognosis. This study focused on the role of E1A‐binding protein p300 (EP300) in the malignant phenotype of HBV‐positive HCC cells and its functional mechanism ...
Fang Xue, Tian‐Feng Sun
wiley   +1 more source