Results 291 to 300 of about 348,739 (321)

Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations. [PDF]

ACS Chem Biol
Lu X, Sauter B, Keller A, Zhanybekova S, Gillingham D.   +4 more
europepmc   +1 more source

HRDPath: An Explainable Multi-Model Deep Learning Architecture for Predicting Homologous Recombination Deficiency from Histopathology Images

Wu C, Banda K, Arora R, Soong TR, Radke M, Dillon M, Nik-Zainal S, Swisher E, Sailem H.   +8 more
europepmc   +1 more source

Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma. [PDF]

Front Med (Lausanne)
Kawanaka Y, Inagaki C, Okura M, Mitani S, Takahama T, Yonesaka K, Chiba Y, Nakagawa K, Kawakami H, Hayashi H.   +9 more
europepmc   +1 more source

CRISPR-Cas targeting in Haloferax volcanii promotes within-species gene exchange by triggering homologous recombination

Choudhary DK, Turgeman-Grott I, Robinzon S, Gophna U.   +3 more
europepmc   +1 more source

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Innovation by homologous recombination

Current Opinion in Chemical Biology, 2013
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L., Smith, Matthew A., Arnold, Frances H.   +2 more
openaire   +3 more sources

Homologous Recombination in Eukaryotes

2012
Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Ravindra, Amunugama, Richard, Fishel
openaire   +2 more sources

Hotspots of homologous recombination

Experientia, 1994
Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
openaire   +2 more sources

Mechanism of Eukaryotic Homologous Recombination

Annual Review of Biochemistry, 2008
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Joseph, San Filippo, Patrick, Sung, Hannah, Klein   +2 more
openaire   +2 more sources

Homologous recombination in a mammalian plasmid

Molecular and General Genetics MGG, 1990
Bovine papillomavirus (BPV) shuttle vectors replicate as a circular plasmid in mouse cell nuclei without impairing host cell viability. We used these vectors to analyze homologous recombination in mammalian cells. When several BPV-based plasmids carrying direct repeats were introduced into C127 cells, we detected many recombinant plasmid molecules that
Y, Kitamura, H, Yoshikura, I, Kobayashi
openaire   +2 more sources